Abstract
Head and neck squamous epithelial carcinogenesis is a complex multistep process that entails a progressive acquisition of alterations in diverse vital cellular pathways. The nature of these alterations and the order of their occurrence have remained unresolved. In the past 15 years, the thrust of research in this field has centered on the epithelial genetic and/or epigenetic changes attendant to their development and progression. Little efforts, however, have been expended on changes in structural or host microenvironment and their role in these tumors. Only recently has the latter topic become the focus of attention. This review will address recent advances in both cellular and structural findings in head and neck squamous carcinoma development and progression. Targeting these events for biological and therapeutic approaches is a desirable goal for future effective treatment of patients with this cancer.
Keywords: GSTP1 genotypes, DNA methylation, Epidermal Growth Factor, Angiogenesis, Epithelial-Mesenchymal Transformation, surrogate markers
Current Cancer Drug Targets
Title: Pathobiology of Head and Neck Squamous Tumorigenesis
Volume: 7 Issue: 7
Author(s): Adel K. El-Naggar
Affiliation:
Keywords: GSTP1 genotypes, DNA methylation, Epidermal Growth Factor, Angiogenesis, Epithelial-Mesenchymal Transformation, surrogate markers
Abstract: Head and neck squamous epithelial carcinogenesis is a complex multistep process that entails a progressive acquisition of alterations in diverse vital cellular pathways. The nature of these alterations and the order of their occurrence have remained unresolved. In the past 15 years, the thrust of research in this field has centered on the epithelial genetic and/or epigenetic changes attendant to their development and progression. Little efforts, however, have been expended on changes in structural or host microenvironment and their role in these tumors. Only recently has the latter topic become the focus of attention. This review will address recent advances in both cellular and structural findings in head and neck squamous carcinoma development and progression. Targeting these events for biological and therapeutic approaches is a desirable goal for future effective treatment of patients with this cancer.
Export Options
About this article
Cite this article as:
El-Naggar K. Adel, Pathobiology of Head and Neck Squamous Tumorigenesis, Current Cancer Drug Targets 2007; 7 (7) . https://dx.doi.org/10.2174/156800907782418338
DOI https://dx.doi.org/10.2174/156800907782418338 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Selenium Derivatives as Cancer Preventive Agents
Current Medicinal Chemistry - Anti-Cancer Agents The Human L1 Element: A Potential Biomarker in Cancer Prognosis, Current Status and Future Directions
Current Molecular Medicine Computational Approaches for the Identification and Optimization of Src Family Kinases Inhibitors
Current Medicinal Chemistry Combination of Anti-EGFR Drugs and Other Molecular Targeted Agents as Anti-Cancer Strategy
Current Cancer Therapy Reviews Opioids Resistance in Chronic Pain Management
Current Neuropharmacology Targeting Chemokine Receptor CXCR4 for Treatment of HIV-1 Infection, Tumor Progression, and Metastasis
Current Topics in Medicinal Chemistry Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer
Current Vascular Pharmacology Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy
Current Pharmacogenomics Small Molecule Aurora Kinases Inhibitors
Current Medicinal Chemistry Targeting Multiplicity: The Key Factor for Anti-Cancer Nanoparticles
Current Medicinal Chemistry PET in Anti-Cancer Drug Development and Therapy
Recent Patents on Anti-Cancer Drug Discovery MicroRNA-31 Inhibits Lung Adenocarcinoma Stem-Like Cells via Down-Regulation of MET-PI3K-Akt Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress
Current Medicinal Chemistry Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy
Current Topics in Medicinal Chemistry 2D QSAR Studies on a Series of Quinazoline Derivatives as Tyrosine Kinase (EGFR) Inhibitor: An Approach to Design Anticancer Agents
Letters in Drug Design & Discovery New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons
Anti-Cancer Agents in Medicinal Chemistry NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization
Current Pharmaceutical Design Development of Amino Acid-Based Radiopharmaceuticals for Tumor Imaging
Mini-Reviews in Medicinal Chemistry Recent Advances and Approaches in Targeting Apoptosis Signaling Pathways for Anti-Cancer Therapeutics
Current Cancer Therapy Reviews MicroRNA Expression Profiling of Epithelial Ovarian Cancer Identifies New Markers of Tumor Subtype
MicroRNA