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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

配备强大的刺猬信号和更好的表观遗传记忆的癌症干细胞：寻找癌症治疗方法的途径

卷 19, 期 11, 2019

页: [877 - 884] 页: 8

弟呕挨: 10.2174/1568009619666190808155432

价格: $65

摘要

通过在癌细胞，与癌症相关的基质细胞，间充质干细胞和癌症干细胞（CSC）的存在下显示异质性，在细胞界描绘了肿瘤的复杂性质。 癌症形成的理论之一被认为是癌症CSCs的理论，该理论被称为引发肿瘤发生的来源。 本质上，这些功能强大的CSC配备了高音速刺猬（SHH）信号传导和表观遗传记忆能力，可支持各种肿瘤标志。 的确，自然界通过限制这些干细胞具有转化为CSC的潜力并进而抑制人类和其他生物的高风险来证明其意图。 简而言之，这项小型综述着眼于SHH信号传导的作用，以允许对支持肿瘤标志的CSC内的表观遗传记忆进行重新编程。 此外，本文探讨了减轻SHH信号传导的治疗方法，这些信号可能会导致CSCs的潜在促癌作用被阻断。

关键词: CSC，表观基因组，基因组，抑制剂，肿瘤，声波刺猬信号，治疗剂。

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