Abstract
Progressive accumulation of cholesterol in the arterial wall causes atherosclerosis, the pathologic process underlying most heart attacks and strokes. Low density lipoprotein (LDL), the major carrier of blood cholesterol, has been implicated in the buildup of cholesterol in atherosclerotic plaques. Endothelial cells that line arteries function to transport LDL into the vessel wall. Models for the mechanism of cholesterol accumulation in atherosclerotic plaques emphasize increased LDL uptake into the vessel wall or increased retention of LDL that has entered the vessel wall. This article reviews the pathways of cholesterol entry and removal, the metabolism, and the physical changes of cholesterol in the vessel wall. How these processes are believed to contribute to cholesterol buildup in atherosclerotic plaques is discussed.
Keywords: Lipoprotein Cholesterol, Atherosclerosis, LDL particle, Phospholipid (PL), Unesterified cholesterol (UC), UC-rich Liposomes, neuraminidase
Current Molecular Medicine
Title: Lipoprotein Cholesterol and Atherosclerosis
Volume: 1 Issue: 6
Author(s): Howard S. Kruth
Affiliation:
Keywords: Lipoprotein Cholesterol, Atherosclerosis, LDL particle, Phospholipid (PL), Unesterified cholesterol (UC), UC-rich Liposomes, neuraminidase
Abstract: Progressive accumulation of cholesterol in the arterial wall causes atherosclerosis, the pathologic process underlying most heart attacks and strokes. Low density lipoprotein (LDL), the major carrier of blood cholesterol, has been implicated in the buildup of cholesterol in atherosclerotic plaques. Endothelial cells that line arteries function to transport LDL into the vessel wall. Models for the mechanism of cholesterol accumulation in atherosclerotic plaques emphasize increased LDL uptake into the vessel wall or increased retention of LDL that has entered the vessel wall. This article reviews the pathways of cholesterol entry and removal, the metabolism, and the physical changes of cholesterol in the vessel wall. How these processes are believed to contribute to cholesterol buildup in atherosclerotic plaques is discussed.
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Cite this article as:
Kruth S. Howard, Lipoprotein Cholesterol and Atherosclerosis, Current Molecular Medicine 2001; 1 (6) . https://dx.doi.org/10.2174/1566524013363212
DOI https://dx.doi.org/10.2174/1566524013363212 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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