Abstract
Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Protein & Peptide Letters
Title: The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity
Volume: 16 Issue: 8
Author(s): Juliana I. dos Santos, Carlos A.H. Fernandes, Angelo J. Magro and Marcos R.M. Fontes
Affiliation:
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Abstract: Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Export Options
About this article
Cite this article as:
dos Santos I. Juliana, Fernandes A.H. Carlos, Magro J. Angelo and Fontes R.M. Marcos, The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923310
DOI https://dx.doi.org/10.2174/092986609788923310 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Prevention and treatment of atherosclerosis with flaxseed -derived compound secoisolariciresinol diglucoside
Current Pharmaceutical Design Multiple Functions of Mammalian Germinal Center Kinases
Current Chemical Biology Insights into the Structure, Function, and Regulation of Human Cytochrome P450 1A2
Current Drug Metabolism TNF alpha Inhibition as Treatment Modality for Certain Rheumatologic and Gastrointestinal Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets β-Carboline Alkaloids: Biochemical and Pharmacological Functions
Current Medicinal Chemistry The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue
CNS & Neurological Disorders - Drug Targets Snake Venom Induced Local Toxicities: Plant Secondary Metabolites as an Auxiliary Therapy
Mini-Reviews in Medicinal Chemistry Association Between Heart Rate Variability and Parkinson’s Disease: A Meta-analysis
Current Pharmaceutical Design Cellular and Physiological Effects of Arginine
Mini-Reviews in Medicinal Chemistry Cardiac Remodeling and Exercise Training in Hypertension
Current Hypertension Reviews Adrenal Insufficiency in Sepsis
Current Pharmaceutical Design Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology TRPV4 Agonists and Antagonists
Current Topics in Medicinal Chemistry Free Radicals Generated by Post-Prandial Oxidative Burst in the Early Alterations of Vascular Contractility
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Induction and Amelioration of Environmental Stress in Isolated Islets Until Transplantation
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Ribosome-inactivating Proteins from Root Tubers and Seeds of Trichosan-thes kirilowii and Other Trichosanthes Species
Protein & Peptide Letters Incidence and Prevention of Thromboembolic Events in One Stage Bilateral Total Hip Arthroplasty: A Systematic Review
Current Vascular Pharmacology Circulatory Syndrome: An Evolution of the Metabolic Syndrome Concept!
Current Cardiology Reviews Geriatric Depression - Review for Primary Care
Current Psychiatry Reviews Current Management of Traumatic Rupture of the Descending Thoracic Aorta
Current Cardiology Reviews