Abstract
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.
Keywords: Dihydropyrimidinone, pharmacology, enzyme/mitotic kinesin inhibitor, receptor antagonist, calcium channel blocker, adrenoceptor, Rho-associated, serine-threonine, polypeptides, kinesin
Mini-Reviews in Medicinal Chemistry
Title:Recent Advance in the Pharmacology of Dihydropyrimidinone
Volume: 12 Issue: 4
Author(s): J.-P. Wan, Y. Pan
Affiliation:
Keywords: Dihydropyrimidinone, pharmacology, enzyme/mitotic kinesin inhibitor, receptor antagonist, calcium channel blocker, adrenoceptor, Rho-associated, serine-threonine, polypeptides, kinesin
Abstract: Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.
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Cite this article as:
J.-P. Wan, Y. Pan , Recent Advance in the Pharmacology of Dihydropyrimidinone, Mini-Reviews in Medicinal Chemistry 2012; 12 (4) . https://dx.doi.org/10.2174/138955712799829267
DOI https://dx.doi.org/10.2174/138955712799829267 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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