Recent Developments in the Use of Palladium on Solid Support in Organic Synthesis

Magne      O. Sydnes

Abstract

As focus is increasing on conducting chemistry in a greener fashion, this implies that chemists need to find new methods for synthetic transformations that are more efficient or open up the possibility for recycling. By such means less waste will be generated. Catalysts on solid supports are one of many avenues that are being explored in order to reach this goal. For the reasons just stated palladium on solid supports is gaining momentum in synthesis. More and more reaction conditions are being developed that enable the use of heterogenic catalysts and a range of solid supports are being explored. The use of a heterogenic catalyst, which can easily be removed post synthesis, has the advantage that it greatly simplifies the work-up of the reaction mixture. It also reduces the amount of palladium remaining in the product. The latter benefit is highly important when the product is a pharmaceutical. Another benefit with having the catalyst on solid supports is that it also offers the opportunity to relatively easily recycle the catalyst. This review will present some of the latest developments in solid supports for palladium, and highlight the use of palladium on solid supports in organic synthesis.

Keywords: Catalyst recycling, cross-coupling reactions, green chemistry, heterogenic catalysis, hydrogenation, nanoparticles, one-pot reactions, palladium, solid support