Abstract
The posttranslational modification of proteins by a single O-linked N-acetylglucosamine (O-GlcNAc) is an intracellular biochemical reaction which is ubiquitous in eukaryotic cells. Two enzymes regulate the process: O-linked Nacetylglucosaminyltransferase (OGT), which attaches O-GlcNAc to serine/threonine residues of proteins, and a a-Nacetylglucosaminidase (O-GlcNAcase), that removes the O-GlcNAc group. The serine or threonine targeted by OGlcNAc can occur at sites modified by other enzymes such as protein kinases. There have been many indications that OGlcNAc modifications are actively involved in the regulation of the immune system and recent results have begun to shed light on possible mechanisms. This review summarizes recent advances in the field of O-GlcNAc modification, with a special attention to its role in the activation of lymphocytes.
Keywords: O-linked N-acetylglucosamine, O-GlcNAc, OGT, T-cell activation, B-cell activation
Current Signal Transduction Therapy
Title: Immune Regulation by the Posttranslational Modification O-GlcNAc
Volume: 5 Issue: 1
Author(s): Alexander Pappa and Danilo Guerini
Affiliation:
Keywords: O-linked N-acetylglucosamine, O-GlcNAc, OGT, T-cell activation, B-cell activation
Abstract: The posttranslational modification of proteins by a single O-linked N-acetylglucosamine (O-GlcNAc) is an intracellular biochemical reaction which is ubiquitous in eukaryotic cells. Two enzymes regulate the process: O-linked Nacetylglucosaminyltransferase (OGT), which attaches O-GlcNAc to serine/threonine residues of proteins, and a a-Nacetylglucosaminidase (O-GlcNAcase), that removes the O-GlcNAc group. The serine or threonine targeted by OGlcNAc can occur at sites modified by other enzymes such as protein kinases. There have been many indications that OGlcNAc modifications are actively involved in the regulation of the immune system and recent results have begun to shed light on possible mechanisms. This review summarizes recent advances in the field of O-GlcNAc modification, with a special attention to its role in the activation of lymphocytes.
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Cite this article as:
Pappa Alexander and Guerini Danilo, Immune Regulation by the Posttranslational Modification O-GlcNAc, Current Signal Transduction Therapy 2010; 5 (1) . https://dx.doi.org/10.2174/157436210790226500
DOI https://dx.doi.org/10.2174/157436210790226500 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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