Abstract
This mini-review summarizes the development of the derivatives and conjugates of Amphotericin B (AMB) which have not been clinically applied so far but are therapeutically promising. Effects of chemical modifications of AMB upon biological activities of the resulting derivatives are discussed. The examples presented include variation of functional groups in AMB, covalent conjugates with other molecules, poly(ethylene glycols) and polysaccharides. Possibilities of targeted delivery of AMB are discussed.
Keywords: Amphotericin B, antimycotics, systemic mycosis, poly(ethylene glycol), polysaccharides, drug targeting, pHsensitivity, β-glucosidase-sensitivity
Mini-Reviews in Medicinal Chemistry
Title: Amphotericin B: From Derivatives to Covalent Targeted Conjugates
Volume: 9 Issue: 11
Author(s): Milos Sedlak
Affiliation:
Keywords: Amphotericin B, antimycotics, systemic mycosis, poly(ethylene glycol), polysaccharides, drug targeting, pHsensitivity, β-glucosidase-sensitivity
Abstract: This mini-review summarizes the development of the derivatives and conjugates of Amphotericin B (AMB) which have not been clinically applied so far but are therapeutically promising. Effects of chemical modifications of AMB upon biological activities of the resulting derivatives are discussed. The examples presented include variation of functional groups in AMB, covalent conjugates with other molecules, poly(ethylene glycols) and polysaccharides. Possibilities of targeted delivery of AMB are discussed.
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Cite this article as:
Sedlak Milos, Amphotericin B: From Derivatives to Covalent Targeted Conjugates, Mini-Reviews in Medicinal Chemistry 2009; 9 (11) . https://dx.doi.org/10.2174/138955709789878178
DOI https://dx.doi.org/10.2174/138955709789878178 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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