Abstract
The aim of this review is to explore the idea that the glycosaminoglycan sugar heparan sulfate (HS), richly concentrated on the plasma membrane of all animal cells studied so far and a major component of extracellular matrices, is by virtue of its ability to modulate protein gradients and signal transduction, the master regulator of stem cell fate (and thus wound healing). Moreover, the interaction between HS and members of the TGF-β superfamily is emerging as a central tenet for stem cells. The potential significance of this interaction is best understood by examining both how HS modulates ligand interactions and stability, and how it maintains protein gradients with varying degrees of specificity. Importantly, HS also regulates the activity of numerous antagonists, thus underscoring its importance as a primary regulator of stem cell fate decisions.
Keywords: Wnt, stem cell, proteoglycan, differentiation, heparin, BMP
Current Stem Cell Research & Therapy
Title: Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals
Volume: 3 Issue: 1
Author(s): Martin Grunert, Victor Nurcombe and Simon M. Cool
Affiliation:
Keywords: Wnt, stem cell, proteoglycan, differentiation, heparin, BMP
Abstract: The aim of this review is to explore the idea that the glycosaminoglycan sugar heparan sulfate (HS), richly concentrated on the plasma membrane of all animal cells studied so far and a major component of extracellular matrices, is by virtue of its ability to modulate protein gradients and signal transduction, the master regulator of stem cell fate (and thus wound healing). Moreover, the interaction between HS and members of the TGF-β superfamily is emerging as a central tenet for stem cells. The potential significance of this interaction is best understood by examining both how HS modulates ligand interactions and stability, and how it maintains protein gradients with varying degrees of specificity. Importantly, HS also regulates the activity of numerous antagonists, thus underscoring its importance as a primary regulator of stem cell fate decisions.
Export Options
About this article
Cite this article as:
Grunert Martin, Nurcombe Victor and Cool M. Simon, Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals, Current Stem Cell Research & Therapy 2008; 3 (1) . https://dx.doi.org/10.2174/157488808783489417
DOI https://dx.doi.org/10.2174/157488808783489417 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Therapeutic Tools
Mini-Reviews in Organic Chemistry MicroRNAs as Cancer Biomarkers
MicroRNA From 2D to 3D - a New Dimension for Modelling the Effect of Natural Products on Human Tissue
Current Pharmaceutical Design Recent Developments on the Role of Mitochondria in Poly(ADP-ribose) Polymerase Inhibition
Current Medicinal Chemistry The Pursuit of Differentiated Ligands for the Glucocorticoid Receptor
Current Topics in Medicinal Chemistry The Role of Cellular Plasticity in Cancer Development
Current Medicinal Chemistry Heterocyclic Drug-polymer Conjugates for Cancer Targeted Drug Delivery
Anti-Cancer Agents in Medicinal Chemistry Function Analysis of Human Protein Interactions Based on a Novel Minimal Loop Algorithm
Current Bioinformatics Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress
Current Medicinal Chemistry Triterpene Derivatives as Inhibitors of Protein Involved in the Inflammatory Process: Molecules Interfering with Phospholipase A2, Cycloxygenase, and Lipoxygenase
Current Drug Targets Role of Angiopoietin-like 4 (ANGPTL4), a Member of Matricellular Proteins: from Homeostasis to Inflammation and Cancer Metastasis
Current Angiogenesis (Discontinued) Non-coding RNAs as Novel Biomarkers in Cancer Drug Resistance
Current Medicinal Chemistry Current Highlights About the Safety of Inorganic Nanomaterials in Healthcare
Current Medicinal Chemistry The Role of Proteomics in Osteoarthritis Pathogenesis Research
Current Drug Targets Meet Our Editorial Board Member
Current Nanomedicine Expression Profiles and Bioinformatics Analysis of Full-length circRNA Isoforms in Gliomas
Current Bioinformatics The Role of Connexins in Carcinogenesis: Review of Current Knowledge
Current Signal Transduction Therapy Calcium and Zinc DTPA Administration for Internal Contamination with Plutonium-238 and Americium-241
Current Pharmaceutical Biotechnology The Parathyroid Hormone Receptorsome and the Potential for Therapeutic Intervention
Current Drug Targets Phytochemical-Mediated Glioma Targeted Treatment: Drug Resistance and Novel Delivery Systems
Current Medicinal Chemistry