Abstract
Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.
Keywords: Leiurus quinquestriatus hebraeus, Androctonus australis, Leiurus quinquestriatus quinquestriatus, Hebraeus, Quinquestriatus
Protein & Peptide Letters
Title: Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates
Volume: 8 Issue: 5
Author(s): Gerardo Corzo, Elba Villegas and Terumi Nakajima
Affiliation:
Keywords: Leiurus quinquestriatus hebraeus, Androctonus australis, Leiurus quinquestriatus quinquestriatus, Hebraeus, Quinquestriatus
Abstract: Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.
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Corzo Gerardo, Villegas Elba and Nakajima Terumi, Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates, Protein & Peptide Letters 2001; 8 (5) . https://dx.doi.org/10.2174/0929866013409256
DOI https://dx.doi.org/10.2174/0929866013409256 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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