Abstract
Pain is a complex disease that usually remains poorly treated or undertreated, especially the neuropathic pain caused by injury to the peripheral or central nervous system. Antagonists of the NMDA receptor complex have emerged as potential drugs for pain management. A strong case is being raised for noncompetitive or uncompetitive antagonists with low-to-moderate affinity and fast on / offset kinetics as drugs with good therapeutic profiles, because of their reduced side effects.
Keywords: excitatory activity, nerve damage, inflammation, ion channels, protein networks, uncompetitive antagonists, synaptic plasticity, drug discovery, pain killers
Mini-Reviews in Medicinal Chemistry
Title: Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain
Volume: 3 Issue: 7
Author(s): Rosa Planells-Cases, Enrique Perez-Paya, Angel Messeguer, Cristina Carreno and Antonio Ferrer-Montiel
Affiliation:
Keywords: excitatory activity, nerve damage, inflammation, ion channels, protein networks, uncompetitive antagonists, synaptic plasticity, drug discovery, pain killers
Abstract: Pain is a complex disease that usually remains poorly treated or undertreated, especially the neuropathic pain caused by injury to the peripheral or central nervous system. Antagonists of the NMDA receptor complex have emerged as potential drugs for pain management. A strong case is being raised for noncompetitive or uncompetitive antagonists with low-to-moderate affinity and fast on / offset kinetics as drugs with good therapeutic profiles, because of their reduced side effects.
Export Options
About this article
Cite this article as:
Planells-Cases Rosa, Perez-Paya Enrique, Messeguer Angel, Carreno Cristina and Ferrer-Montiel Antonio, Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487782
DOI https://dx.doi.org/10.2174/1389557033487782 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Drug Withdrawals in the United States: A Systematic Review of the Evidence and Analysis of Trends
Current Drug Safety The β-Endorphin Role in Stress-Related Psychiatric Disorders
Current Drug Targets Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality
Current Alzheimer Research Prevalence of Frailty in Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-analysis
Current Alzheimer Research Scope and Limitations of The Co-Drug Approach to Topical Drug Delivery
Current Pharmaceutical Design Aluminum Suppresses Effect of Nicotine on Gamma Oscillations (20-40 Hz) in Mouse Hippocampal Slices
CNS & Neurological Disorders - Drug Targets Direct Covalent Modification as a Strategy to Inhibit Nuclear Factor-Kappa B
Current Medicinal Chemistry Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities
Current Pharmaceutical Design Association between Matrix Metalloproteinases, Their Tissue Inhibitor and White Matter Lesions in Mild Cognitive Impairment
Current Alzheimer Research The Fetal Origins of Obesity: Early Origins of Altered Food Intake
Endocrine, Metabolic & Immune Disorders - Drug Targets Molecular Recognition in the Case of Flexible Targets
Current Pharmaceutical Design Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing to Drug Addiction: Effect of Ovarian Hormones
Current Pharmaceutical Design Small Neuroscience: The Nanostructure of the Central Nervous System and Emerging Nanotechnology Applications
Current Nanoscience CRH Receptor Signalling: Potential Roles in Pathophysiology
Current Molecular Pharmacology Development of Pramipexole Hydrochloride Nanocrystals and their Characterization based on <I>In vitro</I> Dissolution Studies
Current Nanomedicine Editorial (Thematic Issue: Allosteric Modulators of G Protein-Coupled Receptors)
Current Topics in Medicinal Chemistry The Effects of General Anesthetics on Synaptic Transmission
Current Neuropharmacology A Novel Technology for Hematopoietic Stem Cell Expansion Using Combination of Nanofiber and Growth Factors
Recent Patents on Nanotechnology Body Image Disturbance and Psychopathology in Children: Research Evidence and Implications for Prevention and Treatment
Current Psychiatry Reviews Pharmacogenetically Tailored Treatments for Heart Disease
Current Pharmaceutical Design