Abstract
Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.
Keywords: non-competitive ampa antagonist,, 2,3-benzodiazepines, pharmacophore model, disco
Letters in Drug Design & Discovery
Title: Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines
Volume: 1 Issue: 3
Author(s): B. Rezessy and S. Solyom
Affiliation:
Keywords: non-competitive ampa antagonist,, 2,3-benzodiazepines, pharmacophore model, disco
Abstract: Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.
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Cite this article as:
Rezessy B. and Solyom S., Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines, Letters in Drug Design & Discovery 2004; 1 (3) . https://dx.doi.org/10.2174/1570180043398948
DOI https://dx.doi.org/10.2174/1570180043398948 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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