Abstract
A series of Schiff bases of menthone has been synthesized using an appropriate synthetic route and characterized using Thin Layer Chromatography and spectral analysis. The synthesized compounds were evaluated for anticonvulsant activity against maximal electro shock (MES) and strychnine induced seizures model in rats. The neurotoxicity and behavioral depressant studies were also carried out using rotorod and tail suspension methods. Results obtained show that, 84% of the compounds afforded significant protection in the MES screen whereas none of them found to be active in strychnine induced seizures. Schiff base with napthyl amine was found to be most active in the series showing activity in the dose of 10 mg/kg in MES test. Majority of the compounds were found to be active in behavioral depressant screening.
Keywords: Schiff base, anticonvulsant activity, menthone, behavioral depressant activity
Central Nervous System Agents in Medicinal Chemistry
Title: Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties
Volume: 7 Issue: 3
Author(s): Jainendra S. Jain, Radheshyam S. Srivastava, Navneet Aggarwal and Reema Sinha
Affiliation:
Keywords: Schiff base, anticonvulsant activity, menthone, behavioral depressant activity
Abstract: A series of Schiff bases of menthone has been synthesized using an appropriate synthetic route and characterized using Thin Layer Chromatography and spectral analysis. The synthesized compounds were evaluated for anticonvulsant activity against maximal electro shock (MES) and strychnine induced seizures model in rats. The neurotoxicity and behavioral depressant studies were also carried out using rotorod and tail suspension methods. Results obtained show that, 84% of the compounds afforded significant protection in the MES screen whereas none of them found to be active in strychnine induced seizures. Schiff base with napthyl amine was found to be most active in the series showing activity in the dose of 10 mg/kg in MES test. Majority of the compounds were found to be active in behavioral depressant screening.
Export Options
About this article
Cite this article as:
Jain S. Jainendra, Srivastava S. Radheshyam, Aggarwal Navneet and Sinha Reema, Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties, Central Nervous System Agents in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/187152407781669143
DOI https://dx.doi.org/10.2174/187152407781669143 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Microglia Phenotype Diversity
CNS & Neurological Disorders - Drug Targets Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
Recent Patents on Anti-Cancer Drug Discovery Autoimmune Diabetes Mellitus: The Importance of Autoantibodies for Disease Prediction and Diagnostic Support
Current Immunology Reviews (Discontinued) Valproic Acid Metabolism and its Consequences on Sexual Functions
Current Drug Metabolism Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
Current Alzheimer Research Cyclosporin and Organ Specific Toxicity: Clinical Aspects, Pharmacogenetics and Perspectives
Current Clinical Pharmacology Antiepileptic Treatments in Developing Countries
Current Pharmaceutical Design Nociceptin/Orphanin FQ Peptide Receptors: Pharmacology and Clinical Implications
Current Drug Targets α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer's Disease
Current Alzheimer Research Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs
CNS & Neurological Disorders - Drug Targets The Use of Antiepileptic Drugs in Paediatric Neurosurgical Conditions
Current Pharmaceutical Design Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases
Current Neuropharmacology Preparation of Tiagabine HCl/2-HPβCD Complex Pellets by Extrusion-Spheronization Using Glycerol Monostearate as Pellet-Aid
Letters in Drug Design & Discovery Inhibition of Monoamine Neurotransmitter Transporters andCentral Nervous System Stimulation Induced by Synthetic Local Anesthetics and Cocaine: A Comparative Review
Current Medicinal Chemistry - Central Nervous System Agents Brain Tumor-Related Epilepsy
Current Neuropharmacology Potential Phytotherapeutic Approaches for the Treatment of Alzheimer’s Disease: An Overview
Current Traditional Medicine Meet Our Editorial Board Member
Current Neuropharmacology Molecular Genetics and Biomarkers of Polyglutamine Diseases
Current Molecular Medicine Advanced Platelet-Rich Fibrin Extract Treatment Promotes the Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells through Activation of Tryptophan Metabolism
Current Stem Cell Research & Therapy Astrocytic Target Mechanisms in Epilepsy
Current Medicinal Chemistry