Abstract
Group A Streptococcus (GAS) is a leading human pathogen that causes a multitude of diseases from pharyngitis, and impetigo, to more severe outcomes such as rheumatoid arthritis and necrotizing fasciitis. GAS remains a global burden as currently no vaccine exists that is completely effective. In this review we highlight recent studies on the virulence of GAS and present several approaches that have extended those findings into aims at combating GAS disease. These and other studies such as recent genome-wide efforts into host-pathogen relationships of GAS disease will likely reveal new targets of intervention. Given the recent rise in GAS strains that have acquired resistance to several types of antibiotics, it is crucial that we continue to increase our knowledge of the mechanisms underlying GAS disease.
Keywords: Group A Streptococcus, antivirulence, vaccines, therapeutics, host-pathogen interaction, GAS, streptococcus pyogenes, M protein, HLA capsule, cytolysin
Current Drug Targets
Title: Knowing is Half the Battle: Targeting Virulence Factors of Group A Streptococcus for Vaccine and Therapeutics
Volume: 13 Issue: 3
Author(s): Clayton L. Thomas and Shaun W. Lee
Affiliation:
Keywords: Group A Streptococcus, antivirulence, vaccines, therapeutics, host-pathogen interaction, GAS, streptococcus pyogenes, M protein, HLA capsule, cytolysin
Abstract: Group A Streptococcus (GAS) is a leading human pathogen that causes a multitude of diseases from pharyngitis, and impetigo, to more severe outcomes such as rheumatoid arthritis and necrotizing fasciitis. GAS remains a global burden as currently no vaccine exists that is completely effective. In this review we highlight recent studies on the virulence of GAS and present several approaches that have extended those findings into aims at combating GAS disease. These and other studies such as recent genome-wide efforts into host-pathogen relationships of GAS disease will likely reveal new targets of intervention. Given the recent rise in GAS strains that have acquired resistance to several types of antibiotics, it is crucial that we continue to increase our knowledge of the mechanisms underlying GAS disease.
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Cite this article as:
L. Thomas Clayton and W. Lee Shaun, Knowing is Half the Battle: Targeting Virulence Factors of Group A Streptococcus for Vaccine and Therapeutics, Current Drug Targets 2012; 13 (3) . https://dx.doi.org/10.2174/138945012799424679
DOI https://dx.doi.org/10.2174/138945012799424679 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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