Abstract
This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters
Current Clinical Pharmacology
Title: Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics
Volume: 4 Issue: 3
Author(s): Dominique Leveque and Francois Jehl
Affiliation:
Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters
Abstract: This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
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Cite this article as:
Leveque Dominique and Jehl Francois, Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics, Current Clinical Pharmacology 2009; 4 (3) . https://dx.doi.org/10.2174/157488409789375348
DOI https://dx.doi.org/10.2174/157488409789375348 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
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