Abstract
Background: Germinal matrix hemorrhage is a leading cause of mortality and morbidity from prematurity. This brain region is vulnerable to bleeding and re-bleeding within the first 72 hours of preterm life. Cerebroventricular expansion of blood products contributes to the mechanisms of brain injury. Consequences include lifelong hydrocephalus, cerebral palsy, and intellectual disability. Unfortunately little is known about the therapeutic needs of this patient population.
Objectives: This review discusses the mechanisms of germinal matrix hemorrhage, the animal models utilized, and the potential therapeutic targets. Conclusion: Potential therapeutic approaches identified in pre-clinical investigations include corticosteroid therapy, iron chelator administration, and transforming growth factor-β pathway modulation, which all warrant further investigation. Thus, effective preclinical modeling is essential for elucidating and evaluating novel therapeutic approaches, ahead of clinical consideration.Keywords: Animal model, drug discovery, experimental, hydrocephalus, neurological dysfunction, translational research.
Current Drug Targets
Title:Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach
Volume: 18 Issue: 12
Author(s): Tim Lekic, Damon Klebe, Pilar Pichon, Katarina Brankov, Sally Sultan, Devin McBride, Darlene Casel, Alhamza Al-Bayati, Yan Ding, Jiping Tang and John H. Zhang*
Affiliation:
- Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall Rm 219, Loma Linda, California, 92354,United States
Keywords: Animal model, drug discovery, experimental, hydrocephalus, neurological dysfunction, translational research.
Abstract: Background: Germinal matrix hemorrhage is a leading cause of mortality and morbidity from prematurity. This brain region is vulnerable to bleeding and re-bleeding within the first 72 hours of preterm life. Cerebroventricular expansion of blood products contributes to the mechanisms of brain injury. Consequences include lifelong hydrocephalus, cerebral palsy, and intellectual disability. Unfortunately little is known about the therapeutic needs of this patient population.
Objectives: This review discusses the mechanisms of germinal matrix hemorrhage, the animal models utilized, and the potential therapeutic targets. Conclusion: Potential therapeutic approaches identified in pre-clinical investigations include corticosteroid therapy, iron chelator administration, and transforming growth factor-β pathway modulation, which all warrant further investigation. Thus, effective preclinical modeling is essential for elucidating and evaluating novel therapeutic approaches, ahead of clinical consideration.Export Options
About this article
Cite this article as:
Lekic Tim, Klebe Damon, Pichon Pilar, Brankov Katarina, Sultan Sally, McBride Devin, Casel Darlene, Al-Bayati Alhamza, Ding Yan, Tang Jiping and Zhang H. John*, Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666160615100538
DOI https://dx.doi.org/10.2174/1389450117666160615100538 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
FDG PET/MR Imaging in Major Neurocognitive Disorders
Current Alzheimer Research Cerebral Palsy: Classification, Etiology and Evolution of Spine Deformity in Children and Adolescents
Current Pediatric Reviews Heat Shock Proteins And Neuroprotection
Recent Patents on DNA & Gene Sequences Carbonic Anhydrase Inhibitors as Anticonvulsant Agents
Current Topics in Medicinal Chemistry Anesthesia Issues in Central Nervous System Disorders
Current Aging Science Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients
Combinatorial Chemistry & High Throughput Screening Diagnosis and Prognosis of Fetal Cardiomyopathies: A Review
Current Pharmaceutical Design Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges
Current Drug Metabolism Increased Alzheimer’s Disease Neuropathology is Associated with Type 2 Diabetes and ApoE ε4 Carrier Status
Current Alzheimer Research Neurosarcoidosis
Current Neuropharmacology Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: A Narrative Review
Infectious Disorders - Drug Targets The Ultimate Outlier: Transitional Care for Persons with Dementia and BPSD
Current Alzheimer Research DNA Polymerases and Oxidative Damage: Friends or Foes?
Current Molecular Pharmacology Menstrual Disorders Related to Eating Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Suicide Gene Therapy Mediated by the Herpes Simplex Virus Thymidine Kinase Gene / Ganciclovir System: Fifteen Years of Application
Current Gene Therapy Copy Number Variations with Isolated Fetal Ventriculomegaly
Current Molecular Medicine The Biological and Clinical Activity of Anti-Malarial Drugs In Autoimmune Disorders
Current Rheumatology Reviews Formaldehyde as a trigger for protein aggregation and potential target for mitigation of age-related, progressive cognitive impairment
Current Topics in Medicinal Chemistry Neurological Assessment of Early Infants
Current Pediatric Reviews Intrathecal Enzyme Replacement Therapy for Mucopolysaccharidosis I: Translating Success in Animal Models to Patients
Current Pharmaceutical Biotechnology