Abstract
The chemical and biological properties of anti-inflammatory marine natural products whose mechanism of action involves inhibition of phospholipase A2 (PLA2), an enzyme of key importance in the biosynthesis of proinflammatory chemical signals and mediators, has been reviewed. Remarkably, most marine natural products display a selective inhibition profile against secretory PLA2 enzymes, with little or null ability to interfere with cytosolic PLA2. Variabilin, a marine furano-terpene, appears to be a notable exception, endowed with a distinctive dual inhibitor profile towards both secretory and cytosolic PLA2 proteins.
Keywords: inflammation, sesterterpenoids, manoalide, pla2 enzymes, cacospongionolides, luffariellolides, petrosaspongiolides
Current Organic Chemistry
Title: Chemistry and Biology of Anti-Inflammatory Marine Natural Products. Phospholipase A2 Inhibitors
Volume: 9 Issue: 14
Author(s): Luigi Gomez-Paloma, Maria C. Monti, Stefania Terracciano, Agostino Casapullo and Raffaele Riccio
Affiliation:
Keywords: inflammation, sesterterpenoids, manoalide, pla2 enzymes, cacospongionolides, luffariellolides, petrosaspongiolides
Abstract: The chemical and biological properties of anti-inflammatory marine natural products whose mechanism of action involves inhibition of phospholipase A2 (PLA2), an enzyme of key importance in the biosynthesis of proinflammatory chemical signals and mediators, has been reviewed. Remarkably, most marine natural products display a selective inhibition profile against secretory PLA2 enzymes, with little or null ability to interfere with cytosolic PLA2. Variabilin, a marine furano-terpene, appears to be a notable exception, endowed with a distinctive dual inhibitor profile towards both secretory and cytosolic PLA2 proteins.
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Gomez-Paloma Luigi, Monti C. Maria, Terracciano Stefania, Casapullo Agostino and Riccio Raffaele, Chemistry and Biology of Anti-Inflammatory Marine Natural Products. Phospholipase A2 Inhibitors, Current Organic Chemistry 2005; 9 (14) . https://dx.doi.org/10.2174/1385272054880205
DOI https://dx.doi.org/10.2174/1385272054880205 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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