Abstract
Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Protein & Peptide Letters
Title: Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation
Volume: 13 Issue: 3
Author(s): Aleksey Lomakin and David B. Teplow
Affiliation:
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Abstract: Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
Export Options
About this article
Cite this article as:
Lomakin Aleksey and Teplow B. David, Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation, Protein & Peptide Letters 2006; 13 (3) . https://dx.doi.org/10.2174/092986606775338515
DOI https://dx.doi.org/10.2174/092986606775338515 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hospital-Based Tobacco Interventions in Pediatric Settings
Current Pediatric Reviews Determination of 7,12-Dimethylbenz[a]Anthracene in Orally Treated Rats by High-Performance Liquid Chromatography and Transfer Stripping Voltammetry
Combinatorial Chemistry & High Throughput Screening Medications Acting on the Dopaminergic System in the Treatment of Alcoholic Patients
Current Pharmaceutical Design Astrocyte-Neuron Interaction at Tripartite Synapses
Current Drug Targets Drug-Induced Pulmonary Hypertension in Newborns: A Review.
Current Vascular Pharmacology Heterogeneity of Cholecystokinin Receptors: A New Interest Towards the Development of CCK2 Agonists
Current Medicinal Chemistry - Central Nervous System Agents Mouse Models of Autoimmune Diseases: Immune Thrombocytopenia
Current Pharmaceutical Design Quantification of Glycyrrhetic Acid in Human Plasma by LC–MS/MS: Application to a Pharmacokinetic Study
Current Pharmaceutical Analysis Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways
Current Pharmaceutical Design Inhibition of Rho/Rho-Kinase as Therapeutic Strategy to Promote CNS Axonal Regeneration
Central Nervous System Agents in Medicinal Chemistry Inhibitors of ABL and the ABL-T315I Mutation
Current Topics in Medicinal Chemistry Modulation of GABAA Receptors by Natural Products and the Development of Novel Synthetic Ligands for the Benzodiazepine Binding Site
Current Drug Targets Solid-State NMR as a Probe of Amyloid Structure
Protein & Peptide Letters Peroxisome Proliferator-Activated Receptor (PPAR) Agonists as Promising New Medications for Drug Addiction: Preclinical Evidence
Current Drug Targets Risk Analysis of Lurasidone in Patients with Schizophrenia and Bipolar Depression
CNS & Neurological Disorders - Drug Targets Diabetic Patients with Psychiatric Illness
Current Diabetes Reviews A Path to Development or Demise ?
Current Neurovascular Research Advances in DNA-Ligands with Groove Binding, Intercalating and/or Alkylating Activity: Chemistry, DNA-Binding and Biology
Current Medicinal Chemistry DNMT3B Promoter Polymorphisms and Risk of Late Onset Alzheimer’s Disease
Current Alzheimer Research Neuroretinal Apoptosis as a Vascular Dysfunction in Diabetic Patients
Current Neuropharmacology