Abstract
Background: Ischemia-modified albumin (IMA) is a systemic indicator of inflammatory diseases and is suggested as an oxidative stress marker.
Objective: To determine the IMA and high-sensitivity C-reactive protein (hsCRP) serum levels for patients with chronic periodontitis (CP) and to evaluate the impact of non-surgical periodontal therapy on serum IMA and hsCRP levels.
Methods: Twenty one systemically healthy patients with CP and 15 systemically and periodontally healthy controls (C) were enrolled in the study. Periodontal pocket depth (PPD), bleeding on probing (BOP) and attachment loss (AL) were recorded at the time of diagnosis and 6 weeks after the nonsurgical periodontal therapy. Blood samples were obtained before and after treatment from all groups, and serum IMA and hsCRP levels were evaluated by ELISA method.
Results: All of the clinical findings were found to be elevated in the CP group in comparison to C group (p<0.05). Levels of IMA and hsCRP were higher in the CP group (p<0.05) and decreased after non-surgical periodontal therapy (p<0.05). Positive correlations were determined between PPD, BOP and hsCRP (p<0.05) as well as between PPD, AL, BOP and IMA levels (p<0.01) before treatment. A significant positive correlation was also observed between hsCRP and IMA (p<0.01) before and after treatment.
Conclusion: IMA is a marker indicating systemic inflammation during periodontal disease, and is significantly reduced as a result of non-surgical periodontal therapy. Therefore, IMA might be suggested as a useful indicator of periodontal disease.
Keywords: Ischemia-modified albumin (IMA), chronic periodontitis (CP), non-surgical periodontal therapy, high-sensitivity C-reactive protein (hsCRP), inflammation, serum levels.
Combinatorial Chemistry & High Throughput Screening
Title:A Novel Systemic Indicator of Periodontal Tissue Damage: Ischemia Modified Albumin
Volume: 21 Issue: 8
Author(s): Mahmure A. Tayman*, Canan Önder, Şivge Kurgan, Muhittin A. Serdar and Meral Günhan
Affiliation:
- Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara,Turkey
Keywords: Ischemia-modified albumin (IMA), chronic periodontitis (CP), non-surgical periodontal therapy, high-sensitivity C-reactive protein (hsCRP), inflammation, serum levels.
Abstract: Background: Ischemia-modified albumin (IMA) is a systemic indicator of inflammatory diseases and is suggested as an oxidative stress marker.
Objective: To determine the IMA and high-sensitivity C-reactive protein (hsCRP) serum levels for patients with chronic periodontitis (CP) and to evaluate the impact of non-surgical periodontal therapy on serum IMA and hsCRP levels.
Methods: Twenty one systemically healthy patients with CP and 15 systemically and periodontally healthy controls (C) were enrolled in the study. Periodontal pocket depth (PPD), bleeding on probing (BOP) and attachment loss (AL) were recorded at the time of diagnosis and 6 weeks after the nonsurgical periodontal therapy. Blood samples were obtained before and after treatment from all groups, and serum IMA and hsCRP levels were evaluated by ELISA method.
Results: All of the clinical findings were found to be elevated in the CP group in comparison to C group (p<0.05). Levels of IMA and hsCRP were higher in the CP group (p<0.05) and decreased after non-surgical periodontal therapy (p<0.05). Positive correlations were determined between PPD, BOP and hsCRP (p<0.05) as well as between PPD, AL, BOP and IMA levels (p<0.01) before treatment. A significant positive correlation was also observed between hsCRP and IMA (p<0.01) before and after treatment.
Conclusion: IMA is a marker indicating systemic inflammation during periodontal disease, and is significantly reduced as a result of non-surgical periodontal therapy. Therefore, IMA might be suggested as a useful indicator of periodontal disease.
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Cite this article as:
Tayman A. Mahmure *, Önder Canan , Kurgan Şivge, Serdar A. Muhittin and Günhan Meral , A Novel Systemic Indicator of Periodontal Tissue Damage: Ischemia Modified Albumin, Combinatorial Chemistry & High Throughput Screening 2018; 21 (8) . https://dx.doi.org/10.2174/1386207321666181018165255
DOI https://dx.doi.org/10.2174/1386207321666181018165255 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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