Abstract
Targeted delivery systems aim to deliver drugs to their intended site of action and as such they are expected to show more desired effects and less unwanted effects. The system itself is composed of a vesicle-encapsulated drug with “target recognition molecules” on the envelop. Ideally, these target recognition molecules, being either small non-peptidic molecules or peptides, are basically high-affinity ligands for a receptor or other protein that is expressed specifically and at high concentrations on the target cells. This review will focus on several widely used examples of target recognition molecules and on how molecular modelling studies have been used in the development of nano drug carrier systems in general.
Keywords: Targeted drug delivery, Nano drug delivery systems, Docking, Molecular dynamics, Central nervous system, Cell penetrating peptides.
Current Topics in Medicinal Chemistry
Title:Target Recognition Molecules and Molecular Modeling Studies
Volume: 17 Issue: 13
Author(s): Burcu Culhaoglu and Atilla Akdemir*
Affiliation:
- Department of Pharmacology, Faculty of Pharmacy, Bezmialem Vakif University, 34093, Istanbul,Turkey
Keywords: Targeted drug delivery, Nano drug delivery systems, Docking, Molecular dynamics, Central nervous system, Cell penetrating peptides.
Abstract: Targeted delivery systems aim to deliver drugs to their intended site of action and as such they are expected to show more desired effects and less unwanted effects. The system itself is composed of a vesicle-encapsulated drug with “target recognition molecules” on the envelop. Ideally, these target recognition molecules, being either small non-peptidic molecules or peptides, are basically high-affinity ligands for a receptor or other protein that is expressed specifically and at high concentrations on the target cells. This review will focus on several widely used examples of target recognition molecules and on how molecular modelling studies have been used in the development of nano drug carrier systems in general.
Export Options
About this article
Cite this article as:
Culhaoglu Burcu and Akdemir Atilla*, Target Recognition Molecules and Molecular Modeling Studies, Current Topics in Medicinal Chemistry 2017; 17 (13) . https://dx.doi.org/10.2174/1568026616666161222100702
DOI https://dx.doi.org/10.2174/1568026616666161222100702 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
AlphaFold in Medicinal Chemistry: Opportunities and Challenges
AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of α7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells
Current Drug Targets The Pharmacology of Human Appetite Expression
Current Drug Targets ATP-Binding Cassette Transporters at the Blood-Brain Barrier in Ischaemic Stroke
Current Pharmaceutical Design Blockade of Furin Activity and Furin-Induced Tumor Cells Malignant Phenotypes By The Chemically Synthesized Human Furin Prodomain
Current Medicinal Chemistry Dry Age-Related Macular Degeneration: Recent Progress of Therapeutic approaches
Current Molecular Pharmacology Targeting the mTOR Pathway in Tumor Malignancy
Current Cancer Drug Targets A Practical Approach to Diagnosis and Treatment of Symptomatic Thromboembolic Events in Children with Acute Lymphoblastic Leukemia: Recommendations of the “Coagulation Defects” AIEOP Working Group
Recent Patents on Cardiovascular Drug Discovery One Pot Green Synthesis of Doxorubicin and Curcumin Loaded Magnetic Nanoparticles and Cytotoxicity Studies
Anti-Cancer Agents in Medicinal Chemistry Estimation of specific activity of 177Lu by `saturation assay` principle using DOTA as ligand
Current Radiopharmaceuticals The Treatment of Autoimmune Hepatitis
Current Clinical Pharmacology Management of Early Stage Cervical Cancer
Reviews on Recent Clinical Trials CD4+CD25+ Regulatory T-Cell Therapy for Allergy, Autoimmune Disease and Transplant Rejection
Inflammation & Allergy - Drug Targets (Discontinued) Follow the ATP: Tumor Energy Production: A Perspective
Anti-Cancer Agents in Medicinal Chemistry Curcumin and its Formulations: Potential Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry The Discovery of Antiangiogenic Molecules: A Historical Review
Current Pharmaceutical Design VEGF Signaling in Cancer Treatment
Current Pharmaceutical Design Modulation of Angiogenesis for Cancer Prevention: Strategies Based On Antioxidants and Copper Deficiency
Current Pharmaceutical Design Functions of S100 Proteins
Current Molecular Medicine Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature
Current Drug Metabolism Irradiation Toxicity and Inflammatory Bowel Diseases (IBD): Review
Reviews on Recent Clinical Trials