Abstract
Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension share a surprising number of similarities and an overlap between their genetics, biological background, underlying personality and temperamental factors, precipitating factors, comorbidity and response to treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge, similarities related to characteristics, manifestation and course, and the results of pharmacological studies related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest researchers and theoreticists of mania of all time.
Keywords: Bipolar disorder, comorbidity, hypertension, mania, temperament, underlying mechanisms.
Current Neuropharmacology
Title:Is Mania the Hypertension of the Mood? Discussion of A Hypothesis
Volume: 15 Issue: 3
Author(s): Zoltan Rihmer, Xenia Gonda and Peter Dome
Affiliation:
Keywords: Bipolar disorder, comorbidity, hypertension, mania, temperament, underlying mechanisms.
Abstract: Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension share a surprising number of similarities and an overlap between their genetics, biological background, underlying personality and temperamental factors, precipitating factors, comorbidity and response to treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge, similarities related to characteristics, manifestation and course, and the results of pharmacological studies related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest researchers and theoreticists of mania of all time.
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Cite this article as:
Rihmer Zoltan, Gonda Xenia and Dome Peter, Is Mania the Hypertension of the Mood? Discussion of A Hypothesis, Current Neuropharmacology 2017; 15 (3) . https://dx.doi.org/10.2174/1570159X14666160902145635
DOI https://dx.doi.org/10.2174/1570159X14666160902145635 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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