Abstract
Recent developments and novel research strategies are adopted widely to discover and develop the new drugs to treat tuberculosis. New antitubercular drugs are urgently needed because tuberculosis remains a global health problem as around nine million new cases are estimated each year with almost two million fatalities. It states the impact and outcomes that have made a significant effect in antitubercular drug development. We are presenting current status of tuberculosis, antitubercular drug development, novel molecular targets, novel agents in clinical and pre-clinical development and some efforts that are being made in the development of novel molecules based on different pharmacophores as lead compounds and recent strategies.
Keywords: Tuberculosis, molecular targets, novel agents in evaluation phase, novel antitubercular agents, novel heterocyclic molecules.
Mini-Reviews in Medicinal Chemistry
Title:Antitubercular Drug Development: Current Status and Research Strategies
Volume: 13 Issue: 11
Author(s): Kuldipsinh P. Barot, Stoyanka Nikolova, Illiyan Ivanov and Manjunath D. Ghate
Affiliation:
Keywords: Tuberculosis, molecular targets, novel agents in evaluation phase, novel antitubercular agents, novel heterocyclic molecules.
Abstract: Recent developments and novel research strategies are adopted widely to discover and develop the new drugs to treat tuberculosis. New antitubercular drugs are urgently needed because tuberculosis remains a global health problem as around nine million new cases are estimated each year with almost two million fatalities. It states the impact and outcomes that have made a significant effect in antitubercular drug development. We are presenting current status of tuberculosis, antitubercular drug development, novel molecular targets, novel agents in clinical and pre-clinical development and some efforts that are being made in the development of novel molecules based on different pharmacophores as lead compounds and recent strategies.
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Barot P. Kuldipsinh, Nikolova Stoyanka, Ivanov Illiyan and Ghate D. Manjunath, Antitubercular Drug Development: Current Status and Research Strategies, Mini-Reviews in Medicinal Chemistry 2013; 13 (11) . https://dx.doi.org/10.2174/13895575113139990076
DOI https://dx.doi.org/10.2174/13895575113139990076 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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