Abstract
A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Medicinal Chemistry
Title:A Novel and Facile Synthetic Approach for Tasigna
Volume: 8 Issue: 5
Author(s): Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang
Affiliation:
Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Abstract: A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
Export Options
About this article
Cite this article as:
Pan Xiaoyan, Lu Wen, Li Pengfei, Wang Fang, Wang Chen, Hu Zhigang and Zhang Jie, A Novel and Facile Synthetic Approach for Tasigna, Medicinal Chemistry 2012; 8 (5) . https://dx.doi.org/10.2174/157340612802084207
DOI https://dx.doi.org/10.2174/157340612802084207 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Cross-over of Anticancer Agents with Osteoclast Activities
Current Cancer Therapy Reviews Chemistry and Theranostic Applications of Radiolabeled Nanoparticles for Cardiovascular, Oncological, and Pulmonary Research
Current Topics in Medicinal Chemistry Interaction of Mesalasine (5-ASA) with Translational Initiation Factors eIF4 Partially Explains 5-ASA Anti-Inflammatory and Anti-Neoplastic Activities
Medicinal Chemistry Current Development and Review of Dynamic Bayesian Network-Based Methods for Inferring Gene Regulatory Networks from Gene Expression Data
Current Bioinformatics Sex Hormones and their Analogues in Neuroimmune Biology
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Nanotechnology as a Promising Strategy for Anticancer Drug Delivery
Current Drug Delivery MicroRNA Regulation of Programmed Cell Death Pathways in Cancer
Current Chemical Biology Mitochondria as a Target for Exercise-Induced Cardioprotection
Current Drug Targets Role of Platelets in Angiogenesis in Health and Disease
Current Angiogenesis (Discontinued) Emerging Endocrine Therapies in the Treatment of HR-Positive Metastatic Breast Cancer
Current Cancer Therapy Reviews Cancer Gene Therapy through Autonomous Parvovirus - Mediated Gene Transfer
Current Gene Therapy Peptides for In Vivo Target-Specific Cancer Imaging
Mini-Reviews in Medicinal Chemistry Preface [Hot Topic: Signal Transduction Therapy: Facts and Visions Executive Editor: Claus Liebmann ]
Current Pharmaceutical Design Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years
Current Topics in Medicinal Chemistry MGBG in Combined Anticancer Chemotherapy
Letters in Drug Design & Discovery Protein-Modified Magnetic Nanoparticles for Biomedical Applications
Current Organic Chemistry Targeted Cancer Immunotherapy Using Ligands of the Tumor Necrosis Factor Super-Family
Current Drug Targets Bladder Cancer Stem Cells
Current Stem Cell Research & Therapy Anti-Cancer Drug Design Using Natural and Synthetic Pharmacophores
Current Organic Chemistry Selenium Compounds Biotransformed by Mushrooms: Not Only Dietary Sources, But Also Toxicity Mediators
Current Nutrition & Food Science