Medicinal Chemistry for Pharmacy Students

Volume: 1

Acid-base Chemistry and Salt Formation

Author(s): Hardeep Singh Saluja and M. O. Faruk Khan

Pp: 76-108 (33)

DOI: 10.2174/9781681086873118010006

* (Excluding Mailing and Handling)


This chapter provides a brief review of the concepts of acid-base chemistry with its applications on drug molecules. It also highlights the significance of salt formations in pharmaceutical products. After studying this chapter, students will be able to: • Comprehend the Arrhenius, Brønstead-Lowry, and Lewis concepts of acids and bases. • Comprehend the ionization, factors controlling ionization, and the acids-base strengths. • Identify the acids and bases occurring in drug molecules and their significance. • Apply the concept of acid-conjugate base and base-conjugate acid in pharmacy. • Apply Henderson-Hasselbalch equation and in pharmacy and drug action and bioavailability. • Interpret pH partition theory and its significance in drug pharmacokinetics. • Illustrate the purpose of salt formation with drug molecules and the acidity or basicity of the salts.

Keywords: Acids, Bases, Henderson-Hasselbalch equation, Ionization, Partition coefficient, pH partition theory, Salt formation, Solubility.

Related Journals
Related Books
© 2024 Bentham Science Publishers | Privacy Policy