Research Article

利用网络药理学揭示复方丰石丁胶囊中多种成分对类风湿关节炎治疗的协同作用机制

卷 19, 期 4, 2019

页: [303 - 314] 页: 12

弟呕挨: 10.2174/1566524019666190405094125

价格: $65

摘要

背景:复方丰石丁胶囊(CFC)是一种中草药配方,包括Alangium platanifolium,Angelicae dahurica,Cynanchum paniculatum和Glycyrrhiza uralensis。 CFC广泛用作抗类风湿性关节炎的临床疗法。但是,其确切的作用机制尚未探索。 方法:为了探索CFC的协同机制,我们设计了一项研究,采用网络药理学方案来筛选与CFC组分相关的作用目标。该研究从PubMed数据库分析了水杨苷,丹皮酚,甘草苷和欧前胡素的目标事实,并探讨了类风湿性关节炎,颈神经痛和坐骨神经痛相关疾病的潜在药理学靶点。 结果:代谢途径增强的结果表明,CFC的化学成分中断了许多免疫相关通路,从而参与了机体的免疫调节,并在风湿病的治疗中发挥作用。总的来说,CFC具有凋亡,氧化应激调节和抗炎作用,其累积用于其针对类风湿性关节炎的临床应用。 结论:最后,我们的研究结果来自本研究的侦察和压缩系统的理论方法,利用四种有效成分的网络药理学机制治疗风湿病,表明与CFC抗风湿病有关的足够的潜在药物靶点。这些有趣的发现有助于进一步体外和体内研究化合物活性成分对风湿病的作用机制。

关键词: 类风湿性关节炎(RA),复方丰石丁胶囊(CFC),多种成分,网络药理学,氧化应激,药理学。

« Previous
[1]
Zhai KF, Duan H, Luo L, et al. Protective effects of paeonol on inflammatory response in IL-1beta-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-kappaB pathway. Inflammopharmacol 2017; 25: 523-32.
[2]
Zhai KF, Duan H, Chen Y, et al. Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial/caspase-mediated pathways. Food Funct 2018; 9: 2070-9.
[3]
Zhang Y, Bai M, Zhang B, et al. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation. Sci Rep 2015; 8: 15924.
[4]
Nanke Y, Yago T, Kotake S. The effects of disease modifying anti-rheumatic drugs on osteoclastogenesis and bone destruction in rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi 2011; 34: 493-500.
[5]
Bohler C, Radner H, Ernst M, et al. Rheumatoid arthritis and falls: the influence of disease activity. Rheumatology 2012; 51: 2051-7.
[6]
Liu SH, Chuang WC, Lam W, Jiang Z, Cheng YC. Safety surveillance of traditional Chinese medicine: Current and future. Drug Saf 2015; 38: 117-28.
[7]
Lu S, Wang Q, Li G, Sun S, Guo Y, Kuang H. The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms. J Ethnopharmacol 2015; 176: 177-206.
[8]
Duan H, Zhai KF, Cao WG, Gao GZ, Shan LL, Zhao L. The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design. Indian J Pharm Edu Res 2017; 51: S631-6.
[9]
Zhai K, Gao G, Cao W, Zhao L, Fang X, Duan H. Simultaneous HPLC determination of four active compounds in fengshiding capsules, a chinese medicine. Indian J Pharm Sci 2014; 76: 445-9.
[10]
Shen P, Shen J, Sun C, et al. A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy. BMC Complement Altern Med 2016; 16: 312.
[11]
Wei Y, Ito Y. Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb “bai zhi”Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography. J Chromatogr A 2006; 1115: 112-7.
[12]
Zhai KF, Duan H, Khan GJ, et al. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways. J Agric Food Chem 2018; 66: 6073-82.
[13]
Wei P, Zhang T, Dong H, et al. Anti-inflammatory and antiviral activities of cynanversicoside A and cynanversicoside C isolated from Cynanchun paniculatum in influenza A virus-infected mice pulmonary microvascular endothelial cells. Phytomedicine 2017; 36: 18-25.
[14]
Xie W, Hao Z, Zhou X, et al. Arbuscular mycorrhiza facilitates the accumulation of glycyrrhizin and liquiritin in Glycyrrhiza uralensis under drought stress. Mycorrhiza 2018; 28: 285-300.
[15]
Zhai KF, Duan H, Cui CY, et al. Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway. J Agric Food Chem 2019; 67: 2856-64.
[16]
Liang X, Li H, Li S. A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study. Mol Biosyst 2014; 10: 1014-22.
[17]
Liu ZH, Sun XB. [Network pharmacology: new opportunity for the modernization of traditional Chinese medicine]. Yao Xue Xue Bao 2012; 47: 696-703.
[18]
Mao Y, Hao J, Jin ZQ, et al. Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients. Oncotarget 2017; 8: 27007-21.
[19]
Lv YN, Li SX, Zhai KF, Kou JP, Yu BY. Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease. Chin J Nat Med 2014; 12: 251-8.
[20]
Li S, Zhang B, Jiang D, Wei Y, Zhang N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 2010; 11: S6.
[21]
Li F, Lv YN, Tan YS, et al. An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases. Acta Pharmacol Sin 2015; 36: 1337-48.
[22]
Hopkins AL. Network pharmacology. Nat Biotechnol 2007; 25: 1110-1.
[23]
Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008; 4: 682-90.
[24]
Wang N, Zhao G, Zhang Y, et al. A network pharmacology approach to determine the active components and potential targets of curculigo orchioides in the treatment of osteoporosis. Med Sci Monit 2017; 23: 5113-22.
[25]
Roelofs MF, Wenink MH, Brentano F, et al. Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA). Ann Rheum Dis 2009; 68: 1486-93.

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