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当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

遗忘性轻度认知障碍的老年人睡眠的自然测量:焦虑症状不解释睡眠障碍

卷 16, 期 3, 2019

页: [233 - 242] 页: 10

弟呕挨: 10.2174/1567205016666190301104645

价格: $65

摘要

背景:睡眠障碍在阿尔茨海默病(AD)中很普遍。在遗忘性轻度认知障碍(aMCI)中,AD的临床前阶段,睡眠质量的恶化也被报道。然而,关于睡眠的哪些方面受到特征性影响,睡眠记录的设置是否影响这些发现,以及焦虑是否可以解释差异,缺乏共识。 目标:目前的研究旨在通过使用家庭内睡眠记录在自然环境中在aMCI中获得全面的睡眠测量来解决这些知识差距。 方法:17名健康老年人和12名患有aMCI的患者佩戴活动表两周,客观地记录习惯性睡眠模式,并完成两晚家庭内多导睡眠监测。 结果:在aMCI中,习惯性睡眠障碍在活动记录仪上很明显,包括睡眠发作后醒来后更多(p = .012,d = 0.99),碎片(p = .010,d = 1.03)和卧床时间(p = .046) ,d = .76)。虽然没有统计学意义,但多导睡眠监测对多导睡眠图产生了很大的影响,其中aMCI显示出比对照更慢的慢波睡眠(p> .05,d = .0.83)。在这项小型研究中,焦虑没有调节小组与睡眠之间的关系。 结论:结果表明,患有aMCI的人的睡眠质量比健康对照更差,这表明睡眠中断更多,慢波睡眠更少,即使在自然环境中也是如此。此外,焦虑症状不会调解这种关系。因此,该研究支持这样的观点,即睡眠障碍可能是aMCI中神经病理学变化的指征,而不是归因于心理因素。

关键词: 睡眠,阿尔茨海默病,轻度认知障碍,认知功能障碍,睡眠障碍,多导睡眠图,神经心理学,活动记录仪。

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