摘要
背景:有几个与边缘系统相关的皮质区域构成海马结构的输出,其细胞和形态学特征在AD的发生和发展中起着重要的作用。我们假设大脑皮层锥体神经元的大小会有显着的差异,阿尔茨海默病患者和对照组之间也会出现半球不对称。与对照组相比,这些差异可能伴随着氟玉B阳性变性皮层神经元数量的增加和DAPI染色皮层神经元核数目的相应减少。这些变化可作为AD死后神经病理诊断的另一个指标。方法:测定阿尔茨海默病患者死后脑区边缘系统5个皮质区和颞平面4个亚区DAPI和氟玉B染色细胞的绝对值。我们还测量了这些受试者边缘系统五个皮质区Ⅲ层锥体神经元的大小。所有测量分别对左右半球进行,以确定两个半球之间的不对称。结果:右侧扣带回IV~VI层、左侧扣带回I~Ⅲ层DAPI染色细胞数明显减少;右侧颞上回向颞平面过渡区IV~VI层,左侧由颞平面向岛状皮质过渡的IV~VI层。我们还观察到Heschl前扣带回I-Ⅲ层、左侧I-Ⅲ层和Heschl右回IV-VI层的氟玉染色细胞数量显著增加。阿尔茨海默病患者右侧扣带回前回、左侧扣带回和后扣带回皮质及海马旁回右侧可见Ⅲ层锥体神经元的缩短。结论:本研究显示颞叶不同皮质区的不对称,可作为AD死后诊断的又一指标。
关键词: 阿尔茨海默病,边缘皮质,颞平面,DAPI,氟玉B,甲酚紫染色,神经变性。
Current Alzheimer Research
Title:Asymmetric Changes in Limbic Cortex and Planum Temporale in Patients with Alzheimer Disease
Volume: 15 Issue: 14
关键词: 阿尔茨海默病,边缘皮质,颞平面,DAPI,氟玉B,甲酚紫染色,神经变性。
摘要: Background: There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the numbers of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Such changes could potentially be used as another marker in postmortem neuropathological diagnosis of AD.
Methods: We measured absolute numbers of DAPI and Fluoro-Jade B stained cells in five cortical areas of the limbic system and four subareas of planum temporale in the post-mortem brains of subjects with Alzheimer disease. We also measured the size of pyramidal neurons in layer III in the five cortical areas of the limbic system in these subjects. All measurements were performed separately for the left and right hemisphere in order to identify asymmetries between the two hemispheres.
Results: We observed a significant decrease in numbers of DAPI stained cells in layers IV-VI of the anterior cingulate gyrus on the right side, in layers I-III of the posterior cingulate gyrus on the left side, in layers IV-VI in the transition region from superior temporal gyrus into planum temporale on the right and in layers IV-VI in the transition from planum temporale to insular cortex on the left. We also observed a significant increase in the numbers of Fluoro-Jade stained cells in layers I-III of the anterior cingulate gyrus and in layers I-III on the left and layers IV-VI of the right gyrus of Heschl. Shortening of the size of layer III pyramidal neurons in subjects with Alzheimer´s disease was found in the anterior cingulate gyrus on the right, in the posterior cingulate gyrus and entorhinal cortex on the left and on the right in the parahippocampal gyrus.
Conclusion: Our study demonstrates asymmetries in different cortical regions of the temporal lobe that can be used as another marker in the postmortem diagnosis of AD.
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Cite this article as:
Asymmetric Changes in Limbic Cortex and Planum Temporale in Patients with Alzheimer Disease, Current Alzheimer Research 2018; 15 (14) . https://dx.doi.org/10.2174/1567205015666181004142659
DOI https://dx.doi.org/10.2174/1567205015666181004142659 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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