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Current Nutrition & Food Science


ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

Potential Cardio-Protective Effects of Green Grape Juice: A Review

Author(s): Latifeh Ahmadi*, Alia El-Kubbe and Sarah K. Roney

Volume 15, Issue 3, 2019

Page: [202 - 207] Pages: 6

DOI: 10.2174/1573401313666170905160818

Price: $65


Unripe grape juice (verjuice) may offer health benefits, including the treatment of cardiovascular disease. The presence of bioactive compounds in verjuice influences blood pressure, inflammatory markers, oxidative stress, endothelial function, fatty streak formation and glycemic level. Studies have shown that the bioactive compounds also affect serum lipid profile, raising LDL cholesterol under certain circumstances. The health-promoting effects of verjuice have been investigated through human and animal trials. This review paper provides a comprehensive summary of the literature on the pharmacological and phytochemical properties of green grape juice. Further research on this juice is needed to quantify the phytochemical composition and support the current findings. Furthermore, future studies are needed to determine the exact amount of verjuice required to exhibit the optimal health effects on humans, as this is currently unknown.

Keywords: Cardiovascular disease, grape juice, verjuice, hypertension, phenolic compounds, phytochemicals.

Graphical Abstract
Setorki M, Asgary S, Eidi A, Haeri Rohani A. Effects of acute verjuice consumption with a high-cholesterol diet on some biochemical risk factors of atherosclerosis in rabbits. Med Sci Monit 2010; 16: BR124-30.
Hayoglu I, Kola O, Kaya C, Özer S, Turkoglu H. Chemical and sensory properties of verjuice, a traditional Turkish non-fermented beverage from kabarcik and yediveren grapes. J Food Process Preserv 2009; 33: 252-63.
Delfan B, Bahmani M, Kazemeini H, et al. Identification of Effective medicinal plants for hyperlipidemia: An ethnobotanical study in lorestan province, west of Iran. Tradit Integr Med 2015; 1(1): 28-34.
Zolfaghari B, Kazemi M, Nematbakhsh M. The effects of unripe grape extract on systemic blood pressure and serum levels of superoxide dismutase, malondialdehyde and nitric oxide in rat. Adv Biomed Res 2015; 4: 109.
Public Health Agency of Canada In: Six types of cardiovascular disease[Internet]. Ottawa: Public Health Agency of Canada 2010.
U.S. Department of Agriculture ARS USDA Database Flavonoid Content Sected Foods
Higdon JV, Frei B. Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 2003; 43: 89-143.
Murota K, Terao J. Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism. Arch Biochem Biophys 2003; 417: 12-7.
Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005; 81: 230S-42S.
Kelly GS. Quercetin. Monograph. Altern Med Rev 2011; 16: 172-94.
Haslam E, Cai Y. Plant polyphenols (vegetable tannins): Gallic acid metabolism. Nat Prod Rep 1994; 11: 41-66.
Xia E, Deng G, Guo Y, Li H. Biological activities of polyphenols from grapes 2010; 622-46.
Hsu CL, Yen GC. Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. Br J Nutr 2007; 98: 727-35.
Gonthier MP, Remesy C, Scalbert A, et al. Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro. Biomed Pharmacother 2006; 60: 536-40.
Rangel-huerta OD, Pastor-villaescusa B, Aguilera CM, Gil A. A systematic review of the efficacy of bioactive compounds in cardiovascular disease. Phenolic Comp 2015; pp. 5177-216.
Gülçin I. Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology 2006; 217: 213-20.
Perry NB, Burgess EJ, Glennie VL. Echinacea standardization: Analytical methods for phenolic compounds and typical levels in medicinal species. J Agric Food Chem 2001; 49: 1702-6.
Yilmaz Y, Toledo RT. Major flavonoids in grape seeds and skins: Antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem 2004; 52: 255-60.
Heiss C, Keen CL, Kelm M. Flavanols and cardiovascular disease prevention. Eur Heart J 2010; 31: 2583-92.
Nance Christina, Melinda Mata, Willliam Shearer Effect of the green tea catechin, epigallocatechin gallate, on innate immune responses in HIV-1 infection as a microbicide (P3170). J Immunol 2013; 190(Suppl. 1): 10.
Peiffer DS, Zimmerman NP, Wang LS, et al. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev Res (PhilaPa) 2014; 7: 574-84.
Marquez A, Serratosa MP, Merida J. Antioxidant activity in relation to the phenolic profile during the winemaking of sweet wines Vitis vinifera cv. Cabernet Sauvignon. Int J Food Sci Technol 2014; 14: 2128-35.
Jyoti Roy A, Stanely Mainzen Prince P. Preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size in experimentally induced myocardial infarction. Eur J Pharmacol 2013; 699: 33-9.
Lee CC, Shen SR, Lai YJ, Wu SC. Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury. Food Funct 2013; 4: 794-802.
Li R, Hettiarachchy N, Rayaprolu S, et al. Phenolics and antioxidant activity of Saskatoon berry (Amelanchier alnifolia) pomace extract. J Med Food 2014; 17: 384-92.
Tuck KL, Hayball PJ. Major phenolic compounds in olive oil: Metabolism and health effects. J Nutr Biochem 2002; 13: 636-44.
Zibaeenezhad MJ, Mohammadi E, Babaie Beigi MA, Mirzamohammadi F, Salehi O. The effects of unripe grape juice on lipid profile improvement. Cholesterol 2012; 2012: 890262.
Alipour M, Davoudi P, Davoudi Z. Effects of unripe grape juice (verjuice) on plasma lipid profile, blood pressure, malondialdehyde and total antioxidant capacity in normal, hyperlipidemic and hyperlipidemic with hypertensive human volunteers. J Med Plants Res 2012; 6: 5677-83.
Aminian B, Massoompour S-M, Sadeghalvaad A, Omrani G-H. Unripe grape juice (verjuice) as a lipid-lowering agent: Fact or fiction. Arch Iran Med 2003; 6: 32-4.
Nematbakhsh M, Zolfaghari B, Eshraghi F, Safari T, Pezeshki Z, Sorooshzadeh SM. The effects of unripe grape extract on systemic blood pressure, nitric oxide production, and response to angiotensin II administration. Pharmacol Res 2013; 5: 60-4.
Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004; 15: 1983-92.
Setorki M, Nazari B, Asgary S, Azadbakht L, Rafieian-Kopaei M. Anti atherosclerotic effects of verjuice on hypocholesterolemic rabbits. Afr J Pharm Pharmacol 2011; 5(8): 1038-45.
Mousa-Al-Reza H, Ziba R, Zakieh K. rad Tania S, Mohammad-Mahdi S. The effect of verjuice on serum lipid levels in mice rendered atherosclerosis. J Biol Act Prod Nat 2011; 1: 229-35.
Aminian A, Aminian B, Hoseinali ANF. Effect of unripe grape juice (verjuice) on plasma lipid levels in rabbits rendered hypercholesterolemic by feeding egg yolk. Acta Med Iran 2006; 44: 230-4.
Hadi HA, Carr CS, Al Suwaidi J. Endothelial dysfunction: Cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag 2005; 1: 183-98.

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