摘要
目的:阿尔茨海默病(AD)是最重要的进行性神经退行性疾病,其特征在于认知和行为障碍。目前,作为微管相关蛋白和AD的主要神经病理学标志,tau为我们提供了一个新的视角来探索进一步的发病机制和治疗策略。 tau蛋白的过度磷酸化和异常聚集,结合清除率下降,形成神经原纤维缠结(NFTs),并在AD中发挥神经毒性作用。 方法:最近的研究旨在防止NFT的沉积并加速NFT的清除。有趣的是,针对tau的免疫策略有效地改善了AD中的tau相关病理学。此外,针对tau的改良疗法应被视为治疗AD的潜在方式。这些进展为AD开辟了新的途径。
关键词: Tau,聚集,磷酸化,NFTs,阿尔茨海默病,治疗。
Current Alzheimer Research
Title:Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies
Volume: 15 Issue: 3
关键词: Tau,聚集,磷酸化,NFTs,阿尔茨海默病,治疗。
摘要: Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a microtubuleassociated protein and a principle neuropathological hallmark of AD, provides us a neoteric perspective to explore further aetiopathogenesis and therapeutic strategy. The hyperphosphorylation and abnormal aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles (NFTs) and exert neurotoxicity in AD.
Methods: Recent investigations aim to prevent the deposition of NFT and accelerate the clearance of NFT. Intriguingly, immunization strategies targeting tau effectively ameliorates the tau-associated pathology in AD. In addition, modified therapies targeting tau should be regarded as a potential way to treat AD. These progresses open new avenues for AD.
Conclusion: Here, we review the recent literature of potential mechanisms of the tau in AD and discuss the modified therapeutic strategies for AD.
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Cite this article as:
Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies, Current Alzheimer Research 2018; 15 (3) . https://dx.doi.org/10.2174/1567205014666170417111859
DOI https://dx.doi.org/10.2174/1567205014666170417111859 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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