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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Exploration of Various Proteins for the Treatment of Alzheimer's Disease

Author(s): Badar ul Islam, Syed Kashif Zaidi, Mohammad Amjad Kamal and Shams Tabrez*

Volume 18, Issue 9, 2017

Page: [808 - 813] Pages: 6

DOI: 10.2174/1389200218666170203110135

Price: $65


Background: Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement are the patho-physiological marker of this devastated disease

Objective: In view of limited treatment option and their success rate, there is an urgent need to explore the vast array of proteomes for the management of AD. These proteins could be therapeutically targeted to prevent the progression of this disease. In the present review, we tried to uncover several proteins that could be exploited in AD therapeutics.

Conclusion: Based on our article, we conclude that proteome based AD treatment needs more refinements and approaches to achieve the desired success rate.

Keywords: Alzheimer's disease, amyloid beta, amyloid precursor protein, apolipoprotein, tau, therapeutics.

Graphical Abstract

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