摘要
现代流感疫苗早已被用于抗击流感,但是,最近的进展强调新替代品的重要性。即使传统的流感疫苗是安全的,且通常是有效的,他们也需要每年上传来预防流感病毒的传播。这一限制和使用鸡胚作为疫苗生产的培养基,是耗时的,且可能牵涉生长新病毒株的潜在生物危害。原核微生物产生的质粒DNA和编码外源蛋白已经成为很有前途的治疗工具。这种技术通过真核细胞使目标基因进行表达,以诱导对目标病原体的保护性免疫反应。本文讨论了选择最佳的用于治疗和预防流感的核酸疫苗的策略。具体而言,我们更新了流感病毒核酸疫苗的发展、所有涉及的技术、其主要特点、适用性和技术特点,以获得对抗流感感染的最佳选择。
关键词: 基因表达,流感,流感感染,质粒DNA,纯化,疫苗。
Current Gene Therapy
Title:Influenza Plasmid DNA Vaccines: Progress and Prospects
Volume: 15 Issue: 6
Author(s): Diana Bicho, Joao Antonio Queiroz and Candida Teixeira Tomaz
Affiliation:
关键词: 基因表达,流感,流感感染,质粒DNA,纯化,疫苗。
摘要: Current influenza vaccines have long been used to fight flu infectious; however, recent advances highlight the importance of produce new alternatives. Even though traditional influenza vaccines are safe and usually effective, they need to be uploaded every year to anticipate circulating flu viruses. This limitation together with the use of embryonated chicken eggs as the substrate for vaccine production, is time-consuming and could involve potential biohazards in growth of new virus strains. Plasmid DNA produced by prokaryote microorganisms and encoding foreign proteins had emerged as a promising therapeutic tool. This technology allows the expression of a gene of interest by eukaryotic cells in order to induce protective immune responses against the pathogen of interest. In this review, we discuss the strategies to choose the best DNA vaccine to be applied in the treatment and prevention of influenza. Specifically, we give an update of influenza DNA vaccines developments, all involved techniques, their main characteristics, applicability and technical features to obtain the best option against influenza infections.
Export Options
About this article
Cite this article as:
Diana Bicho, Joao Antonio Queiroz and Candida Teixeira Tomaz , Influenza Plasmid DNA Vaccines: Progress and Prospects, Current Gene Therapy 2015; 15 (6) . https://dx.doi.org/10.2174/1566523215666150929111048
DOI https://dx.doi.org/10.2174/1566523215666150929111048 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Use of TNF Family Ligands and Receptors and Agents which Modify their Interaction as Therapeutic Agents
Current Drug Targets Specific Nutritional Needs for Children: Are Children Small Adults?
Current Pediatric Reviews Angiogenesis and Microvasculature in the Female Reproductive Organs: Physiological and Pathological Implications
Current Pharmaceutical Design Novel Oral Anticoagulants for Venous Thromboembolism with Special Emphasis on Risk of Hemorrhagic Complications and Reversal Agents
Current Drug Therapy The Molecular Mechanisms and Rational Design of Anti-Diabetic Vanadium Compounds
Current Topics in Medicinal Chemistry Research Advancements in Porcine Derived Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Dorsal Stream Dysfunction in Children. A Review and an Approach to Diagnosis and Management
Current Pediatric Reviews Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems
Current Drug Targets Characterization of Bovine Tau-Preparations by Two-Dimensional Gel Electrophoresis
Protein & Peptide Letters Modulation of Matrix Metalloproteinase Activity by Tobacco Cigarette Smoke
Current Chemical Biology Novel Therapeutic Targets for the Treatment of Depression
Current Medicinal Chemistry - Central Nervous System Agents The Impact of Hypothermia on the Pharmacokinetics of Drugs Used in Neonates and Young Infants
Current Pharmaceutical Design Antipsychotic-like Effects of Cannabidiol and Rimonabant: Systematic Review of Animal and Human Studies
Current Pharmaceutical Design Mucopolysaccharidosis Type III (Sanfilippo Syndrome): Emerging Treatment Strategies
Current Pharmaceutical Biotechnology Clinico-Pathologic Function of Cerebral ABC Transporters – Implications for the Pathogenesis of Alzheimers Disease
Current Alzheimer Research Mitochondrial, Metabolic and Genotoxic Effects of Antiretroviral Nucleoside Reverse-Transcriptase Inhibitors
Anti-Infective Agents in Medicinal Chemistry Inflammasome Activation in Chronic Glomerular Diseases
Current Drug Targets Brain Inflammation, Cholesterol, and Glutamate as Interconnected Participants in the Pathology of Alzheimers Disease
Current Pharmaceutical Design The Multidrug Resistance Mechanisms and their Interactions with the Radiopharmaceutical Probes Used for an In Vivo Detection
Current Drug Metabolism Therapeutic Application of Intrabodies Against Age-Related Neurodegenerative Disorders
Current Pharmaceutical Design