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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

The Role of Autophagy in the Gut Pathogens Clearance and Evasion

Author(s): Jun Hu, Yangfan Nie and Xianghua Yan

Volume 16, Issue 7, 2015

Page: [632 - 645] Pages: 14

DOI: 10.2174/1389203716666150630134205

Price: $65


The mammalian intestine harbors a mass of microorganisms that is essential to maintain intestinal epithelium homeostasis and health. However, some microbes can damage the epithelial mucosal barrier to utilize nutrients for their survival and growth. Autophagy is a highly conserved cellular process that targets cytoplasmic damaged organelles and some cellular molecules to lysosome for degradation. Accumulating studies have demonstrated that autophagy plays an important role in the innate immune system in response to different gut pathogens. For instance, autophagy can be induced to mediate the process of pathogenic infection during pathogens invasion. In this review, we mainly discuss the steps of autophagy pathway mediated by microbes and the role of autophagy in the gut pathogens clearance and evasion.

Keywords: Antimicrobial peptides, autophagosome, autophagy, clearance, evasion, gut pathogens.

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