Abstract
Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.
Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade
Current Neurovascular Research
Title: Cerebrovascular Damage as a Cause for Alzheimers Disease
Volume: 2 Issue: 4
Author(s): C. Humpel and J. Marksteiner
Affiliation:
Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade
Abstract: Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.
Export Options
About this article
Cite this article as:
Humpel C. and Marksteiner J., Cerebrovascular Damage as a Cause for Alzheimers Disease, Current Neurovascular Research 2005; 2 (4) . https://dx.doi.org/10.2174/156720205774322610
DOI https://dx.doi.org/10.2174/156720205774322610 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetic Risk Factors in Cerebrovascular Disorders and Cognitive Deterioration
Current Genomics Sleep Disturbance is Associated with Incident Dementia and Mortality
Current Alzheimer Research Network Pharmacology of Ayurveda Formulation <i>Triphala</i> with Special Reference to Anti-Cancer Property
Combinatorial Chemistry & High Throughput Screening Telmisartan Promotes Potential Glucose Homeostasis in Stroke-Resistant Spontaneously Hypertensive Rats via Peroxisome Proliferator-Activated Receptor γ Activation
Current Neurovascular Research Neuroprotective effects of the securinine-analogues: identification of Allomargaritarine as a lead compound
CNS & Neurological Disorders - Drug Targets Nonalcoholic Fatty Liver Disease and Cardiovascular Disease
Current Pharmaceutical Design Heart Failure and Cognitive Impairment: Clinical Relevance and Therapeutic Considerations
Current Cardiology Reviews A Review of Wavelet Denoising in MRI and Ultrasound Brain Imaging
Current Medical Imaging Anti-Viral Agents in Neurodegenerative Disorders: New Paradigm for Targeting Alzheimer’s Disease
Recent Patents on Anti-Infective Drug Discovery Drug Trials in Dementia: Challenging Ethical Dilemmas
Current Alzheimer Research Small Molecule TGF-beta Mimetics as Potential Neuroprotective Factors
Current Alzheimer Research Editorial (Thematic Issue: Effective and Promising Treatments for Neurological Disorders and Cancer)
Current Pharmaceutical Design The Adult Patient with Eisenmenger Syndrome: A Medical Update After Dana Point Part I: Epidemiology, Clinical Aspects and Diagnostic Options
Current Cardiology Reviews Elucidation of Pathophysiology and Treatment of Neuropathic Pain
Central Nervous System Agents in Medicinal Chemistry Evaluation of Acetylcholinesterase and Prolyl Oligopeptidase Inhibition of Novel Amino acid-functionalized Stigmasterol and Ursolic Acid Derivatives
Current Organic Chemistry Editorial:Genomics and Epigenomics of Tumor and Aging Cells
Current Genomics Biomarkers in Lone Atrial Fibrillation-An Additional ‘Fine Tuning’ of Risk?
Current Pharmaceutical Design Diagnosis of Mild Cognitive Impairment Using Cognitive Tasks: A Functional Near-Infrared Spectroscopy Study
Current Alzheimer Research Methods for Identifying Cardiovascular Agents: A Review
Recent Patents on Cardiovascular Drug Discovery Proteomics and Cardiovascular Disease: An Update
Current Medicinal Chemistry