Abstract
The design and development of radiolabelled estradiol derivatives has been an important area of research due to their recognized value in breast cancer management. The estrogen receptor (ER) is a relevant biomarker in the diagnosis, prognosis and prediction of the therapeutic response in estrogen receptor positive breast tumours. Hence, many radioligands based on estradiol derivatives have been proposed for targeted functional ER imaging. The main focus of this review is to survey the current knowledge on estradiol-based radioiodinated receptor ligands synthesis for breast tumour functional imaging. The main preclinical and clinical achievements in the field will also be briefly presented to make the manuscript more comprehensive.
Keywords: Breast cancer, tumor targeting, SPECT, radioiodination, estrogen receptor, estradiol, Nucleophilic Substitution, SAR
Call for Papers in Thematic Issues
Federated Learning for Secure Medical Imaging Data Sharing in Healthcare Networks.
Decentralised machine learning model training is known as federated learning. Instead of sharing the original data, federated learning shares model changes, such as gradient information, which inherently safeguards the data kept on each device. But since model updates are dependent on the original data, they may expose private information. For ...read more
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