Abstract
Anapyrexia, which is a regulated fall in core temperature, is beneficial for animals and humans when the oxygen supply is limited, e.g., hypoxic, ischemic, or histotoxic hypoxia, since at low body temperature the tissues require less oxygen due to Q10. Besides hypoxia, anapyrexia can be induced various exogenous and endogenous substances, named cryogens. However, there are only a few reports investigating endogenous cryogens in mammals. We have experienced one patient who suffered from severe hypothermia. The patient seemed to be excessively producing endogenous peptidergic cryogenic substances the molecular weight of which may be greater than 30 kDa. In animal studies, the patients cryogen appeared to affect metabolic functions, including thermogenic threshold temperatures, and then to produce hypothermia. Since endogenous cryogenic substances may be regarded as useful tool in human activities, e.g., during brain hypothermia therapy or staying in a space station or spaceship, further studies may be needed to identify human endogenous cryogens.
Keywords: Anapyrexia, poikilothermia, hypothermia, metabolic depression, Cryogens, hypoxia, thermogenic threshold temperatures, antipyretics
Current Protein & Peptide Science
Title: Possible Human Endogenous Cryogens
Volume: 12 Issue: 4
Author(s): Osamu Shido and Naotoshi Sugimoto
Affiliation:
Keywords: Anapyrexia, poikilothermia, hypothermia, metabolic depression, Cryogens, hypoxia, thermogenic threshold temperatures, antipyretics
Abstract: Anapyrexia, which is a regulated fall in core temperature, is beneficial for animals and humans when the oxygen supply is limited, e.g., hypoxic, ischemic, or histotoxic hypoxia, since at low body temperature the tissues require less oxygen due to Q10. Besides hypoxia, anapyrexia can be induced various exogenous and endogenous substances, named cryogens. However, there are only a few reports investigating endogenous cryogens in mammals. We have experienced one patient who suffered from severe hypothermia. The patient seemed to be excessively producing endogenous peptidergic cryogenic substances the molecular weight of which may be greater than 30 kDa. In animal studies, the patients cryogen appeared to affect metabolic functions, including thermogenic threshold temperatures, and then to produce hypothermia. Since endogenous cryogenic substances may be regarded as useful tool in human activities, e.g., during brain hypothermia therapy or staying in a space station or spaceship, further studies may be needed to identify human endogenous cryogens.
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Cite this article as:
Shido Osamu and Sugimoto Naotoshi, Possible Human Endogenous Cryogens, Current Protein & Peptide Science 2011; 12 (4) . https://dx.doi.org/10.2174/138920311795906682
DOI https://dx.doi.org/10.2174/138920311795906682 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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