Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

Title: Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

Volume: 7 Issue: 1

Author(s): H. R. Parri and K. T. Dineley

Affiliation:

Keywords: Nicotinic, cholinergic, amyloid, Alzheimer's disease, neuroprotection, α7, review

Abstract: Elevated amyloid-β peptide (Aβ) and loss of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimers disease (AD). Since the discovery of an Aβ - nAChR interaction, much effort has been expended to characterize the consequences of high versus low concentrations of Aβ on nAChRs. This review will discuss current knowledge on the subject at the molecular, cellular, and physiological levels with particular emphasis on understanding how Aβ - nAChR interaction may contribute to normal physiological processes as well as the etiology of AD.

Cite this article as:

Parri R. H. and Dineley T. K., Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences, Current Alzheimer Research 2010; 7 (1) . https://dx.doi.org/10.2174/156720510790274464