Abstract
We suggest that band 3 aggregation begins in the membranes of middle-aged erythrocytes causing the entire band 3 molecule to undergo conformation change as erythrocytes age. The alteration in band 3 structure exposes a previously protected proteolytic region to the cytosolic environment in the old erythrocytes, allowing a membrane bound protease to cleave at that site. Band 3 fragment is then forced to the surface of the membrane, causing such a cell to be recognized as immunologically foreign, resulting in its removal from the circulation.
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