T Lymphocytes as Targets of Gene Transfer with Moloney-Type Retroviral Vectors

Epigenetic mechanisms including DNA methylation, histone post-translational modifications, non-coding RNAs and chromatin remodeling play crucial roles in gene expression. Aberrant epigenetic changes are often correlated with human diseases and metabolic disorders. Since gene expression can be activated/inactivated by reversible epigenetic mechanisms, increasing studies have been focused on epigenetic regulation in ...read more

Prostate cancer is the second most frequently diagnosed cancer in men worldwide and remains a leading cause of cancer mortality. While advances in androgen receptor–targeted therapies, radioligand treatment, and immunotherapy have improved outcomes, resistance and disease progression continue to present major challenges. Recent breakthroughs in gene and cell therapies — ...read more

Programmed cell death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more

Gene and cell therapies rely on a gene delivery system which is safe and effective. Both viral and non-viral vector systems are available with specific pros and cons. The choice of a vector system is largely dependent on the application which is a balance between target tissue/disease and safety, efficacy ...read more