Innate Immune Receptors and IRF Family Transcription Factors

Author(s): Takashi Fujita, Mitsutoshi Yoneyama

Journal Name: Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
Continued as Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 4 , Issue 1 , 2005


Toll like receptors (TLRs) function as signaling receptors for pathogen-derived molecules and provoke innate immune responses, which are preparatory for initiating acquired immunity. Each TLR triggers both common and unique signals, resulting in the activation of a specific set of transcription factors and hence the activation of common and specific target genes. Some members of the Interferon Regulatory Factor (IRF) family of transcription factors are specifically activated by TLR signaling and participate in the critical processes of innate immunity. Recently, a non-TLR receptor that recognizes viral double stranded RNA and participates in the antiviral innate responses was identified.

Keywords: interferon, toll like receptors, dendritic cells, cytoplasm, phosphorylation

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Article Details

Year: 2005
Page: [29 - 33]
Pages: 5
DOI: 10.2174/1568014053005291

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