Atrial Fibrillation Following Cardiac Surgery: Established and Emerging Strategies of Prevention

Author(s): Nasir Shariff, Abdul Aleem, Larry E. Jacobs, Christopher Cutitta, Sultan M. Siddique, Matthew W. Martinez, Martin E. Matsumura, Ronald Freudenberger

Journal Name: Recent Patents on Cardiovascular Drug Discovery (Discontinued)

Volume 6 , Issue 3 , 2011


More than 250,000 patients undergo cardiac surgery every year. Although advances in surgical techniques have reduced the peri-operative morbidity and mortality in these patients, atrial fibrillation persists to commonly occur following these surgeries. Traditional therapies have reduced their occurrence; however there are still a significant number of patients who develop this complication. Newer and non-conventional medications are being studied to reduce this cardiac arrhythmia. This review will elaborate on the patho-physiology, and prevention of this arrhythmia. We also aim to summarize recent investigated and patented medications which may result in more effective strategies for prophylaxis against this cardiac arrhythmia.

Keywords: Cardiac surgery, post-operative atrial fibrillation, preventive strategy, BETA-BLOCKERS, ANGIOTENSIN INHIBITORS, N-ACETYLCYSTEIN, DRONEDARONE, OMEGA FATTY ACIDS, STATINS, STEROIDS

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Article Details

Year: 2011
Page: [168 - 174]
Pages: 7
DOI: 10.2174/157489011797377121
Price: $65

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