T Cell Receptor Bias in Humans

Author(s): John J. Miles, Rebekah M. Brennan, Scott R. Burrows

Journal Name: Current Immunology Reviews (Discontinued)

Volume 5 , Issue 1 , 2009


The last decade has seen escalating reports of T cell receptor (TcR) bias across all facets of human immunity. These reports describe a phenomenon whereby certain peptide-bound major histocompatibility complexes (pMHC) elicit T cell expansions which bear TcRs with identical or near-identical sequences across unrelated individuals. These observations are indeed curious given the vastness of the naive T cell repertoire and indicate that powerful Darwinian selection forces influence both thymic and post-thymic pMHC-driven selection. This review catalogues examples of selection bias in the human αβ T cell response and presents the proposed mechanisms that steer their supremacy in the blood.

Keywords: T cell receptor, T cell repertoire, immunodominance, major histocompatibility complex, peptide

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Article Details

Year: 2009
Page: [10 - 21]
Pages: 12
DOI: 10.2174/157339509787314404

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