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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Review Article

Pharmacological Applications of Diphenylamine and Its Derivative as Potent Bioactive Compound: A Review

Author(s): Arvind Kumar* and Arun K. Mishra

Volume 14 , Issue 3 , 2018

Page: [217 - 233] Pages: 17

DOI: 10.2174/1573407213666170301155550

Price: $65


In 1863, Diphenylamine (DPA) was prepared by Hoffmann by the destructive distillation of different triphenylmethane dyes. DPA are naturally occurring compounds, present in onions, leaves of black and green tea and peel of citrus fruits. DPA derivatives belong to the category of Non Steroidal Anti-inflammatory Drugs (NSAIDs). Diclofenac, chemically called 2-(2,6-dichloranilino) phenylacetic acid, is a well-known NSAID. Other important compounds are tolfenamic acid, flufenamic acid and mefenamic acid, etc. DPA derivatives are claimed for several important biological activities which include anti-microbial, analgesic, anti-inflammatory, anti-convulsant and anti-cancer activities. Many more compounds have been discovered and many are still being focused.

The key goal of this article is to show up the different derivatives and the pharmacological activities of DPA. Hence, it can be concluded that DPA and its derivatives possess significant therapeutic functions and many potent derivatives are still to be discovered.

Keywords: Diphenylamine, anti-microbial activity, analgesic activity, anti-inflammatory activity anti-convulsant activity, anticancer activity, anti-tubercular activity.

Graphical Abstract

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