Abstract
The key strengths of electrospray over any other ionisation techniques are its soft nature and its ability to produce multiply charged ions. This combination is ideal for the study of non-covalent interactions. In this review article, we cover the basics of studying non-covalent interactions by mass spectrometry - illustrated with examples from our own and other labs - and discuss the current mass spectrometry based methods used for understanding and characterising noncovalent protein complexes.
Keywords: Mass Spectrometry, Electrospray Ionisation, Non-Covalent Interactions, ESI mass spectrum, PROTEIN-LIGAND INTERACTIONS
Combinatorial Chemistry & High Throughput Screening
Title: Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions
Volume: 12 Issue: 2
Author(s): Bryan J. McCullough and Simon J. Gaskell
Affiliation:
Keywords: Mass Spectrometry, Electrospray Ionisation, Non-Covalent Interactions, ESI mass spectrum, PROTEIN-LIGAND INTERACTIONS
Abstract: The key strengths of electrospray over any other ionisation techniques are its soft nature and its ability to produce multiply charged ions. This combination is ideal for the study of non-covalent interactions. In this review article, we cover the basics of studying non-covalent interactions by mass spectrometry - illustrated with examples from our own and other labs - and discuss the current mass spectrometry based methods used for understanding and characterising noncovalent protein complexes.
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Cite this article as:
McCullough J. Bryan and Gaskell J. Simon, Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions, Combinatorial Chemistry & High Throughput Screening 2009; 12 (2) . https://dx.doi.org/10.2174/138620709787315463
DOI https://dx.doi.org/10.2174/138620709787315463 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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