Chemogenomics with Peptide Secondary Structure Mimetics

Author(s): Masakatsu Eguchi, Michael McMillan, Cu Nguyen, Jia-Ling Teo, Emil Y. Chi, William R. Henderson Jr., Michael Kahn.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 6 , Issue 7 , 2003

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Abstract:

There is increasing evidence that redox regulation of transcription, particularly activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB), is important in inflammatory diseases. Human thioredoxin (TRX), a member of the oxidoreductase superfamily, was initially identified, as a factor which augments the production of interleukin-2 receptor alpha (IL-2R α) in human T-cell lymphotropic virus type 1 (HTLV-1) infected patient T-cells. Substrates for the redox activity of TRX bind the active site cleft in extended strand structure. The rapid generation of high numbers of peptide secondary structure mimetics through solid-phase synthesis is a key technology for the identification of pharmaceutical leads based on such protein-peptide interactions. In this manuscript, we describe a chemogenomic approach utilizing an extended strand templated library to develop small molecule inhibitors to validate oxidoreductase molecular targets in a murine asthma model.

Keywords: chemogenomics, peptide secondary, structure mimetics, activator protein-1, nuclear factor kappa b, human thioredoxin

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2003
Page: [611 - 621]
Pages: 11
DOI: 10.2174/138620703771981197
Price: $58

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