Antiviral Properties Against HIV of Water Soluble Copper Carbosilane Dendrimers and their EPR Characterization

Author(s): M. Galan, J. Sanchez-Rodriguez, M. Cangiotti, S. Garcia-Gallego, J.L. Jimenez, R. Gomez, M.F. Ottaviani, M.A. Munoz-Fernandez, F.J. de la Mata.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 29 , 2012

Abstract:

We describe here the use of anionic carbosilane dendrimers to obtain new copper complexes. UV-Vis and a computer aided analysis of the EPR spectra provided information about the coordination modes of copper depending on the nature of the dendrimer and about the geometry and structure of the complexes in solution. Some of these metallo-dendrimers have been tested “in vitro” as antiviral compounds in the inhibition of HIV infection in pre and post-infection treatment.

Keywords: Anionic, antiviral properties, carboxylate, copper, dendrimers, EPR, HIV, microbicide, sulfonate, transition-metal ions

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Article Details

VOLUME: 19
ISSUE: 29
Year: 2012
Page: [4984 - 4994]
Pages: 11
DOI: 10.2174/0929867311209024984
Price: $58

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