Antiviral Properties Against HIV of Water Soluble Copper Carbosilane Dendrimers and their EPR Characterization

Title:Antiviral Properties Against HIV of Water Soluble Copper Carbosilane Dendrimers and their EPR Characterization

Volume: 19 Issue: 29

Author(s): M. Galan, J. Sanchez-Rodriguez, M. Cangiotti, S. Garcia-Gallego, J.L. Jimenez, R. Gomez, M.F. Ottaviani, M.A. Munoz-Fernandez and F.J. de la Mata

Affiliation:

Keywords: Anionic, antiviral properties, carboxylate, copper, dendrimers, EPR, HIV, microbicide, sulfonate, transition-metal ions

Abstract: We describe here the use of anionic carbosilane dendrimers to obtain new copper complexes. UV-Vis and a computer aided analysis of the EPR spectra provided information about the coordination modes of copper depending on the nature of the dendrimer and about the geometry and structure of the complexes in solution. Some of these metallo-dendrimers have been tested “in vitro” as antiviral compounds in the inhibition of HIV infection in pre and post-infection treatment.

Cite this article as:

Galan M., Sanchez-Rodriguez J., Cangiotti M., Garcia-Gallego S., Jimenez J.L., Gomez R., Ottaviani M.F., Munoz-Fernandez M.A. and de la Mata F.J., Antiviral Properties Against HIV of Water Soluble Copper Carbosilane Dendrimers and their EPR Characterization, Current Medicinal Chemistry 2012; 19 (29) . https://dx.doi.org/10.2174/0929867311209024984