Title:Antiviral Properties Against HIV of Water Soluble Copper Carbosilane Dendrimers and their EPR Characterization
VOLUME: 19 ISSUE: 29
Author(s):M. Galan, J. Sanchez-Rodriguez, M. Cangiotti, S. Garcia-Gallego, J.L. Jimenez, R. Gomez, M.F. Ottaviani, M.A. Munoz-Fernandez and F.J. de la Mata
Affiliation:Departamento de Quimica Inorganica, Universidad de Alcala, Campus Universitario. Edificio de Farmacia, 28871 Alcala de Henares. Spain.
Keywords:Anionic, antiviral properties, carboxylate, copper, dendrimers, EPR, HIV, microbicide, sulfonate, transition-metal ions
Abstract:We describe here the use of anionic carbosilane dendrimers to obtain new copper complexes. UV-Vis and a computer aided
analysis of the EPR spectra provided information about the coordination modes of copper depending on the nature of the dendrimer and
about the geometry and structure of the complexes in solution. Some of these metallo-dendrimers have been tested “in vitro” as antiviral
compounds in the inhibition of HIV infection in pre and post-infection treatment.
