An efficient solvent and catalyst-free synthesis of new Betti base derivatives via Mannich-type one-pot threecomponent
condensation reaction of aminodiazines, salicylaldehyde and naphthols under solvent-free conditions is described.
The reactions occur at 80 oC giving high to excellent yields of the products. The work-up procedure is very simple
and the products do not require further purification with column chromatography.
Keywords: Aminodiazine, Betti base, naphthol, salicylaldehyde, solvent-free, three- component, 2-aminopyrimidine, temperature, aminonaphthols
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