An Efficient Green MCR Protocol for the Synthesis of New Betti Bases via Mannich-Type Reaction

Author(s): Abolfazl Olyaei, Mojgan Zarnegar, Mahdieh Sadeghpour, Mortaza Rezaei.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 6 , 2012

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Abstract:

An efficient solvent and catalyst-free synthesis of new Betti base derivatives via Mannich-type one-pot threecomponent condensation reaction of aminodiazines, salicylaldehyde and naphthols under solvent-free conditions is described. The reactions occur at 80 oC giving high to excellent yields of the products. The work-up procedure is very simple and the products do not require further purification with column chromatography.

Keywords: Aminodiazine, Betti base, naphthol, salicylaldehyde, solvent-free, three- component, 2-aminopyrimidine, temperature, aminonaphthols

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [451 - 456]
Pages: 6
DOI: 10.2174/157017812801322499

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