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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solid-Phase Microwave Assisted Synthesis of Curcumin Analogs

Author(s): Dinesh Pore, Ramesh Alli, Achanta S.C. Prabhakar, Rajashekar R. Alavala, Umasankar Kulandaivelu and Shireesha Boyapati

Volume 9, Issue 6, 2012

Page: [447 - 450] Pages: 4

DOI: 10.2174/157017812801322417

Price: $65

Abstract

Turmeric contains three important analogs, curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), collectively called as curcuminoids. Curcumin, the most abundant of these curcuminoids is reported to have antioxidant, anti-inflammatory, neuroprotective, antimicrobial, nematocidal, antimutagenic, anticarcinogenic, antiretroviral and chemopreventive activities. Curcumin (a symmetric β diketone) analogs 3a-e were synthesized from β- diketones and aromatic aldehydes using solid phase microwave irradiation method in presence of boric acid in diethanolamine, acetic acid (1:1) with reduced reaction time and enhanced %yield. Various clays like Alumina (neutral), Silica gel and Montmorillonite K10 were used as solid phase catalysts where alumina was found to be efficient in the synthesis of curcumin analogs

Keywords: Aldol condensation, boron-assisted, curcumin analogs, microwave irradiation, regioselective, solid-phase, anticarcinogenic, antimutagenic, chemopreventive, antiretroviral


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