Search Result "lead compounds."


Components of Successful Lead Generation

Journal: Current Topics in Medicinal Chemistry
Volume: 5 Issue: 4 Year: 2005 Page: 421-439
Author(s): Andrew M. Davis, David J. Keeling, John Steele, Nicholas P. Tomkinson, Alan C. Tinker

Computational Chemistry as an Integral Component of Lead Generation

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 5 Issue: 7 Year: 2005 Page: 677-683
Author(s): Olivier Roche, Wolfgang Guba

Validation of the Neuroinflammation Cycle as a Drug Discovery Target Using Integrative Chemical Biology and Lead Compound Development with an Alzheimers Disease-Related Mouse Model

Journal: Current Alzheimer Research
Volume: 2 Issue: 2 Year: 2005 Page: 197-205
Author(s): Wenhui Hu, Hantamalala Ralay Ranaivo, Jeffrey M. Craft, Linda J. Van Eldik, D. Martin Watterson

Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection

Journal: Current Topics in Medicinal Chemistry
Volume: 5 Issue: 1 Year: 2005 Page: 1033-1038
Author(s): Suresh K. Balani, Gerald T. Miwa, Liang-Shang Gan, Jing-Tao Wu, Frank W. Lee

Carbohydrate Scaffolds for the Production of Bioactive Compounds

Journal: Current Organic Synthesis
Volume: 2 Issue: 2 Year: 2005 Page: 153-173
Author(s): L. Cipolla, F. Peri, B. La Ferla, C. Redaelli, F. Nicotra

High Throughput Sonication: Evaluation for Compound Solubilization

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 8 Issue: 6 Year: 2005 Page: 499-512
Author(s): Kevin Oldenburg, Douglas Pooler, Kurt Scudder, Christopher Lipinski, Michele Kelly

The Novartis Compound Archive - From Concept to Reality

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 8 Issue: 6 Year: 2005 Page: 513-519
Author(s): U. Schopfer, C. Engeloch, J. Stanek, M. Girod, A. Schuffenhauer, E. Jacoby, P. Acklin

Web Enabling Technology for the Design, Enumeration, Optimization and Tracking of Compound Libraries

Journal: Current Topics in Medicinal Chemistry
Volume: 5 Issue: 8 Year: 2005 Page: 773-783
Author(s): Bradley P. Feuston, Subhas J. Chakravorty, John F. Conway, J. C. Culberson, Joseph Forbes, Bryan Kraker, Patricia A. Lennon, Craig Lindsley, Georgia B. McGaughey, Ralph Mosley, Robert P. Sheridan, Mario Valenciano, Simon K. Kearsley

Chemical Aspects of Coumarin Compounds for the Prevention of Hepatocellular Carcinomas

Journal: Current Medicinal Chemistry - Anti-Cancer Agents
Volume: 5 Issue: 1 Year: 2005 Page: 47-51
Author(s): Toshihiro Okamoto, Tadashi Kobayashi, Shinichi Yoshida

Coagulation and Cancer Therapy: The Potential of Natural Compounds

Journal: Current Genomics
Volume: 6 Issue: 6 Year: 2005 Page: 461-469
Author(s): G. Z. Justo, C. V. Ferreira

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