Frontiers in Clinical Drug Research – Hematology is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology. The first volume of this series features 6 chapters that cover a variety of topics including: Computational methods, molecular docking, and molecular dynamics simulation Recent advances in the treatment of Beta-Thalassemia Major Research on multiple myeloma and leukemia Molecular imaging in hematology

Despite remarkable progress in fighting against myocardial infarction, the thrombotic complications of the coronary artery are still a significant cause of morbidity and mortality worldwide. Treatment options for arterial thrombosis include either relatively old drugs such as streptokinase, and newer agents that are either approved by the FDA or still undergoing clinical trials. These options make some room for questions that lead to a conclusion for the best combination of drugs for treating patients with acute coronary syndromes. The handbook combines available information from basic hematology, cardiology and clinical trials and presents practical bed-side solutions for clinicians working with patients suffering from acute coronary syndromes. Readers will learn about the pathogenesis and diagnosis of thrombosis, thrombogenesis and fibrinolysis. Newer antithrombotic agents, cardiac diseases, venous thromboembolism are also covered. Health professionals will have quick access to relevant and organized information which also includes visual and tabular guides as well as some recommendations from professional societies.

Type A acute aortic dissection (TAAAD) is an acute cardiovascular condition that is normally associated with genetic conditions such as Marfan Syndrome, but it can also occur in patients with no known predisposing risk factors. TAAD is associated with extremely high mortality (over 20% of documented cases in medical literature) if not addressed on time. Surgical management of TAAAD also varies tremendously depending on the causative pathology. Techniques to manage TAAAD cover the entire spectrum of methods employed in cardiac surgery ranging from a simple replacement of the ascending aorta to aortic root sparing or replacement, and an aortocoronary bypass to total arch and descending aortic stenting involving hypothermic circulatory arrest or other cerebral protection strategies. New medical evidence suggests that concomitant, intraoperative management of the arch and descending aorta minimizes the need for subsequent surgeries in patients who are operated upon for TAAAD. Coupled with new diagnostic technology available to medical professionals, better long-term patient outcomes for TAAD treatment are now a reality. Recent Advances in Acute Type A Aortic Dissection presents a collection of comprehensive reviews from many experts on TAAAD. Cardiac surgeons can benefit from this volume by learning about current medical opinions and consensuses on risk factors (including genetic predisposition), diagnostic modalities, intraoperative management, surgical options, cerebral protection strategies, and long-term follow up procedures on acute TAAAD.

Frontiers in Myocardia is an eBook series which compiles information about the structure and function of myocardial (the heart muscles) and includes updated reviews on the recent developments in the treatment of associated diseases such as angina, cardiac arrhythmias and myocardial infarction. Advances in research on clinical sepsis in the last few decades have lead to the use of new concepts and treatment paradigms that have been tested and implemented in the clinical setting of Intensive Care Units around the world. An integrative approach towards understanding the pathophysiology of cardiac dysfunction in septic patients can, therefore, lead to better patient outcomes. The first volume of this series, Septic Cardiomyopathy: from bench-to-bedside, integrates new and old information about the molecular mechanisms, histopathological and electrophysiological alterations with novel findings for diagnosing treating septic cardiomyopathy. This eBook attempts to bridge the gap between basic and clinical scientists and presents new data on different aspects of cardiac physiology during critical illness in a single volume. Chapters in this volume also cover cardiovascular changes that occur as a consequence of sepsis including metabolic, mitochondrial arrhythmic changes. This eBook will add significant value to medical students, cardiac physicians and medical scientists engaged in the field of critical care medicine.

Cardiovascular mortality in women is more frequent than breast cancer mortality, a fact which is often overlooked. Women's Heart and Estrogens explores this important women’s health issue with respect to estrogen levels (before and after menopause) as the hormone has been known to mediate cardiovascular effects in women. The handbook includes a description of the structure and biological activity of estrogen and follows up with a detailed reference on the genetics behind estrogen and its effect on the cardiovascular system. Subsequent chapters cover the effects of estrogens on the stages of atherogenesis, actions of estrogens on the on the vascular wall and on cardiovascular metabolic pathways, causes leading to the development of early onset of coronary heart disease in young women (such as vasculitis and autoimmune diseases)[Obaid ur Rahman1] , hypercoagulable states, myocardial infarction in hallucinogenic drug abusers, non-atherosclerotic and atherosclerotic coronary heart disease, hormone replacement therapy and postmenopausal risk factors. Medical professionals will also find handy guidelines for cardiovascular disease prevention in women. Women's Heart and Estrogens offers knowledge to readers in a clear and simple manner with detailed images and summaries in each chapter. Guidelines are also presented in a chronological context which demonstrates the development of cardiovascular disease prevention and risk management strategies for women over the years.

Frontiers in Clinical Drug Research – Hematology is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the eBook series covers a range of topics including medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology. The second volume of this series features 5 chapters that cover a variety of topics including: -Chronic myeloid leukemia -Bispecific and multivalent antibodies -Natural Killer cells therapy for bone marrow transplantation -Nanoparticles in health and disease -Monoclonal antibody therapy for lymphoma

Ischemic cardiomyopathy is considered as the main cause of heart failure in industrialized countries. The condition can occur at any age, but its prevalence increases with age. In general, careful evaluation of the patient's history and physical examination can provide useful information about the underlying causes. Several biomarkers and laboratory variables are very important parameters for physicians during the clinical decision making. Echocardiography along with other imaging and heart failure management techniques can provide key information to clinicians about these parameters. This information can be used to provide adequate medical interventions and improve patient health while reducing the risk of sudden death due to cardiac arrest. This volume of Frontiers in Heart Failure brings forth information about several topics related to assessing the risk of heart failure and treating patients who may be at high risk. Chapters in this volume cover topics such as ischemia, echocardiography, pharmacotherapy, interventional techniques and device therapies. Novel therapies, such as gene and cell strategies are also covered in this volume.

This volume of Frontiers in Heart Failure comprehensively covers the gap between clinical management of heart failure and advanced molecular imaging techniques (SPECT, PET, MRI etc.). These techniques provide valuable evidence to cardiologists for the evaluation and follow-up of heart failure patients. It brings forth established research data regarding the pathophysiology, clinical presentations and therapy of heart failure, in a balance between clinical items and molecular imaging modalities. Readers will also find additional chapters on hybrid cardiovascular imaging techniques as well as guidelines on imaging artifacts and radiation protection. This volume is a useful resource for radiologists, cardiologists, cardiac care nurses and medical physicists.

Herbal Medicine: Back to the Future compiles expert reviews on the application of herbal medicines (including Ayurveda, Chinese traditional medicines and alternative therapies) to treat different ailments. The book series demonstrates the use of sophisticated methods to understand traditional medicine, while providing readers a glimpse into the future of herbal medicine. This volume presents reviews of traditional Chinese medicine and other nutritional therapies useful for treating cardiovascular diseases, including: - cardiovascular benefits of the European Olive and bottle gourd - a review of the cardiovascular benefits of Naoxintong - herbal and micronutrient supplements for cardiovascular disease patients - herbal remedies for atherosclerosis - cardio-protective alkaloids This volume is essential reading for all researchers in the field of natural product chemistry and pharmacology. Medical professionals involved in cardiovascular care who seek to improve their knowledge about herbal medicine and alternative therapies will also benefit from the contents of the volume.